Anti-Somatostatin Receptor 2 antibody - Extracellular domain (ab140933)
Key features and details
- Rabbit polyclonal to Somatostatin Receptor 2 - Extracellular domain
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
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Overview
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Product name
Anti-Somatostatin Receptor 2 antibody - Extracellular domain
See all Somatostatin Receptor 2 primary antibodies -
Description
Rabbit polyclonal to Somatostatin Receptor 2 - Extracellular domain -
Host species
Rabbit -
Specificity
BLAST analysis of the peptide immunogen showed no homology with other Human proteins. -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat, Horse, Cow, Dog, Pig, Monkey, Opossum, Common marmoset, Bat, Elephant -
Immunogen
Synthetic peptide from 17 amino acid region within 2nd extracellular domain of Human Somatostatin Receptor 2 (P30874).
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Positive control
- Human pancreas, islet of Langerhans tissue
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. -
Storage buffer
pH: 7.4
Preservative: 0.1% Sodium azide
Constituent: 99% PBS -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab140933 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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IHC-P |
Use a concentration of 24 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
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Notes |
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IHC-P
Use a concentration of 24 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Target
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Function
Receptor for somatostatins-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. In RIN-5F cells, this receptor inhibits calcium entry by suppressing voltage dependent calcium-channels. -
Tissue specificity
Cerebrum and kidney. In lesser amounts in jejunum, colon and liver. -
Sequence similarities
Belongs to the G-protein coupled receptor 1 family. -
Cellular localization
Cell membrane. - Information by UniProt
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Database links
- Entrez Gene: 282083 Cow
- Entrez Gene: 403472 Dog
- Entrez Gene: 100052744 Horse
- Entrez Gene: 6752 Human
- Entrez Gene: 20606 Mouse
- Entrez Gene: 497059 Pig
- Entrez Gene: 54305 Rat
- Omim: 182452 Human
see all -
Alternative names
- Somatostatin receptor type 2 antibody
- SRIF-1 antibody
- SRIF1 antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (2)
ab140933 has been referenced in 2 publications.
- Sato A & Hara Y Protein expression of somatostatin receptor 2, somatostatin receptor 5 and dopamine D2 receptor in normal pituitary gland and ACTH-secreting pituitary adenoma in dogs. Res Vet Sci 119:61-66 (2018). IHC-P ; Dog . PubMed: 29864631
- Silva CB et al. Expression of somatostatin receptors (SSTR1-SSTR5) in meningiomas and its clinicopathological significance. Int J Clin Exp Pathol 8:13185-92 (2015). PubMed: 26722517