Anti-Sorbitol Dehydrogenase antibody (ab123497)

Overview

  • Product nameAnti-Sorbitol Dehydrogenase antibody
    See all Sorbitol Dehydrogenase primary antibodies
  • Description
    Rabbit polyclonal to Sorbitol Dehydrogenase
  • Tested applicationsSuitable for: IPmore details
    Unsuitable for: WB
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Sheep, Rabbit, Cow, Dog, Pig, Chimpanzee, Ferret, Rhesus monkey, Orangutan, Bat
  • Immunogen

    Synthetic peptide, corresponding to a region within the N terminal amino acids 1-50 of Human Sorbitol Dehydrogenase using the numbering given in entry NP_003095.2.

  • Positive control
    • HeLa whole cell lysate

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab123497 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IP Use at 2-10 µg/mg of lysate.
  • Application notesIs unsuitable for WB.
  • Target

    • FunctionConverts sorbitol to fructose. Part of the polyol pathway that plays an important role in sperm physiology. May play a role in the sperm motility by providing an energetic source for sperm.
    • Tissue specificityExpressed in kidney and epithelial cells of both benign and malignant prostate tissue. Expressed in epididymis (at protein level).
    • Sequence similaritiesBelongs to the zinc-containing alcohol dehydrogenase family.
    • Cellular localizationMitochondrion membrane. Cell projection > cilium > flagellum. Associated with mitochondria of the midpiece and near the plasma membrane in the principal piece of the flagellum. Also found in the epididymosome, secreted by the epididymal epithelium and that transfers proteins from the epididymal fluid to the sperm surface.
    • Information by UniProt
    • Database links
    • Alternative names
      • DHSO_HUMAN antibody
      • L iditol 2 dehydrogenase antibody
      • L-iditol 2-dehydrogenase antibody
      • OTTHUMP00000161939 antibody
      • SDH antibody
      • Sorbitol dehydrogenase 1 antibody
      • Sorbitol dehydrogenase antibody
      • SORD 1 antibody
      • SORD antibody
      • SORD1 antibody
      see all

    Anti-Sorbitol Dehydrogenase antibody images

    • Immunoprecipitation from HeLa whole cell lysate (1 mg for IP, 20% of IP loaded), using ab123497 at 6 µg/mg lysate for IP.
      Subsequent Western blot detection used an antibody which recognized an downstream epitope of Sorbitol Dehydrogenase at 0.4 µg/ml.
      Detection: Chemiluminescence with an exposure time of 10 seconds

    References for Anti-Sorbitol Dehydrogenase antibody (ab123497)

    ab123497 has not yet been referenced specifically in any publications.

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