Recombinant
RabMAb

Anti-Sorbitol Dehydrogenase antibody [EPR15857] (ab189248)

Overview

  • Product name
    Anti-Sorbitol Dehydrogenase antibody [EPR15857]
    See all Sorbitol Dehydrogenase primary antibodies
  • Description
    Rabbit monoclonal [EPR15857] to Sorbitol Dehydrogenase
  • Tested applications
    Suitable for: IP, WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human Sorbitol Dehydrogenase aa 1-100. The exact sequence is proprietary.
    Database link: Q00796

  • Positive control
    • Human fetal kidney, human fetal liver, mouse kidney, mouse spleen, rat kidney, C6, Hela, PC-3 cell lysates,
  • General notes

    This product is a recombinant rabbit monoclonal antibody.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

Properties

Applications

Our Abpromise guarantee covers the use of ab189248 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IP 1/50.
WB 1/1000 - 1/20000. Predicted molecular weight: 38 kDa.

Target

  • Function
    Converts sorbitol to fructose. Part of the polyol pathway that plays an important role in sperm physiology. May play a role in the sperm motility by providing an energetic source for sperm.
  • Tissue specificity
    Expressed in kidney and epithelial cells of both benign and malignant prostate tissue. Expressed in epididymis (at protein level).
  • Sequence similarities
    Belongs to the zinc-containing alcohol dehydrogenase family.
  • Cellular localization
    Mitochondrion membrane. Cell projection > cilium > flagellum. Associated with mitochondria of the midpiece and near the plasma membrane in the principal piece of the flagellum. Also found in the epididymosome, secreted by the epididymal epithelium and that transfers proteins from the epididymal fluid to the sperm surface.
  • Information by UniProt
  • Database links
  • Alternative names
    • DHSO_HUMAN antibody
    • L iditol 2 dehydrogenase antibody
    • L-iditol 2-dehydrogenase antibody
    • OTTHUMP00000161939 antibody
    • SDH antibody
    • Sorbitol dehydrogenase 1 antibody
    • Sorbitol dehydrogenase antibody
    • SORD 1 antibody
    • SORD antibody
    • SORD1 antibody
    see all

Images

  • All lanes : Anti-Sorbitol Dehydrogenase antibody [EPR15857] (ab189248) at 1/20000 dilution

    Lane 1 : Human fetal kidney
    Lane 2 : Human fetal liver
    Lane 3 : Hela cell lysate
    Lane 4 : PC-3 cell lysate

    Lysates/proteins at 20 µg per lane.

    Secondary
    Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

    Predicted band size : 38 kDa
  • All lanes : Anti-Sorbitol Dehydrogenase antibody [EPR15857] (ab189248) at 1/5000 dilution

    Lane 1 : Mouse kidney
    Lane 2 : Mouse spleen
    Lane 3 : Rat kidney
    Lane 4 : C6 lysate

    Lysates/proteins at 10 µg per lane.

    Secondary
    Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

    Predicted band size : 38 kDa
  • Immunoprecipitation of Human fetal liver labeling Sorbitol Dehydrogenase with ab189248 at 1/50 dilution and Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000.

References

ab189248 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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