Overview

  • Product name
  • Description
    Goat polyclonal to SorLA
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse
    Predicted to work with: Rat, Rabbit, Cow, Dog, Human
  • Immunogen

    Synthetic peptide:

    TGFSDDVPMVIA

    , corresponding to C terminal amino acids 2203-2214 of Human SORL1.

  • Positive control
    • Mouse brain lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab22814 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notes
    WB: Use at a concentration of 0.3 - 1 µg/ml. Predicted molecular weight: 246 kDa.
    Peptide ELISA: antibody detection limit dilution 1:4,000.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor-associated protein (RAP). Could play a role in cell-cell interaction.
    • Tissue specificity
      Expressed mainly in brain, where it is most abundant in the cerebellum, cerebral cortex and the occipital pole; low expression in the putamen and the thalamus. According to PubMed:9157966, found in spinal cord, testis, liver, kidney and pancreas with detectable levels in placenta, lung and heart. According to PubMed:8940146, expressed in the prostate, ovary, thyroid and spleen, but not found in kidney, liver, lung, skeletal muscle, bone marrow and adrenals.
    • Sequence similarities
      Belongs to the SORL1 family.
      Contains 5 BNR repeats.
      Contains 1 EGF-like domain.
      Contains 6 fibronectin type-III domains.
      Contains 11 LDL-receptor class A domains.
      Contains 5 LDL-receptor class B repeats.
    • Post-translational
      modifications
      The propeptide removed in the N-terminus may be cleaved by furin or homologous proteases.
    • Cellular localization
      Membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • C11orf32 antibody
      • FLJ21930 antibody
      • FLJ39258 antibody
      • gp250 antibody
      • LDLR relative with 11 ligand binding repeats antibody
      • LDLR relative with 11 ligand-binding repeats antibody
      • Low density lipoprotein receptor relative with 11 ligand binding repeats antibody
      • Low-density lipoprotein receptor relative with 11 ligand-binding repeats antibody
      • LR 11 antibody
      • LR11 antibody
      • LRP 9 antibody
      • LRP9 antibody
      • Mosaic protein LR11 antibody
      • SORL 1 antibody
      • SORL_HUMAN antibody
      • SORL1 antibody
      • SorLA 1 antibody
      • SorLA antibody
      • SorLA-1 antibody
      • Sortilin related receptor antibody
      • Sortilin related receptor L(DLR class) A repeats containing antibody
      • Sortilin-related receptor antibody
      • Sorting protein related receptor containing LDLR class A repeats antibody
      • Sorting protein-related receptor containing LDLR class A repeats antibody
      see all

    Images

    References

    ab22814 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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