The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 1 µg/ml. Detects a band of approximately 30 kDa (predicted molecular weight: 23 kDa).
Use at an assay dependent dilution.
FunctionMay be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction Enhances Wnt signaling and inhibits TGF-beta signaling (By similarity). Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner.
Tissue specificityHighly expressed in kidney and weakly in lung.
Sequence similaritiesBelongs to the sclerostin family. Contains 1 CTCK (C-terminal cystine knot-like) domain.