FunctionActs as transcription regulator that binds target promoter DNA and bends the DNA. Binds to the sequences 5'-AACAAT-'3 or 5'-AACAAAG-3'. Modulates transcriptional regulation via WNT3A. Inhibits Wnt signaling. Promotes degradation of activated CTNNB1. Plays a key role in the regulation of embryonic development. Required for normal looping of the embryonic heart tube. Required for normal development of the definitive gut endoderm. Probable transcriptional activator in the premeiotic germ cells.
Tissue specificityExpressed in adult heart, lung, spleen, testis, ovary, placenta, fetal lung, and kidney. In normal gastrointestinal tract, it is preferentially expressed in esophagus, stomach and small intestine than in colon and rectum.
Involvement in diseaseDefects in SOX17 are the cause of vesicoureteral reflux type 3 (VUR3) [MIM:613674]. VUR3 is a disease belonging to the group of congenital anomalies of the kidney and urinary tract. It is characterized by the reflux of urine from the bladder into the ureters and sometimes into the kidneys, and is a risk factor for urinary tract infections. Primary disease results from a developmental defect of the ureterovesical junction. In combination with intrarenal reflux, the resulting inflammatory reaction may result in renal injury or scarring, also called reflux nephropathy. Extensive renal scarring impairs renal function and may predispose patients to hypertension, proteinuria, renal insufficiency and end-stage renal disease.
SRY related HMG box transcription factor SOX17 antibody
Transcription factor SOX-17 antibody
Transcription factor SOX17 antibody
Anti-SOX17 antibody [3B10] images
Immunocytochemistry/ Immunofluorescence - Anti-SOX17 antibody [3B10] (ab84990)Image courtesy of an anonymous AbReview.
Immunocytochemical immunoflurescence analysis of acetone-fixed human iCell® Neurons, labelling SOX17 with ab84990 at a dilution of1/500 incubated for 24 hours at 4°C in 10% FBS. Blocking was with 5% serum incubated for 1 hour at 25°C. Secondary was a goat anti-mouse polyclonal Alexa Fluor® 594 conjugate at 1/1000.
ab84990 staining HeLa cells by immunofluorescence.
References for Anti-SOX17 antibody [3B10] (ab84990)
This product has been referenced in:
Pennarossa G et al. Brief demethylation step allows the conversion of adult human skin fibroblasts into insulin-secreting cells. Proc Natl Acad Sci U S A110:8948-53 (2013).
Read more (PubMed: 23696663) »
Zhang X et al. Terminal differentiation and loss of tumorigenicity of human cancers via pluripotency-based reprogramming. Oncogene : (2012).
Read more (PubMed: 22777357) »