Anti-SOX2 [EPR3131] antibody (DyLight® 488) (ab139849)

Overview

  • Product nameAnti-SOX2 [EPR3131] antibody (DyLight® 488)See all SOX2 primary antibodies ...
  • Description
    Rabbit monoclonal [EPR3131] to SOX2 (DyLight® 488)
  • ConjugationDyLight® 488. Ex: 493nm, Em: 518nm
  • Tested applicationsICC/IF more details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide against a region within the Human SOX2 protein

  • Positive control
    • ICC: NCCIT cells.
  • General notesProduced under U.S. Patent No. 5,675,063. Stable for 6 months from date of receipt.

Applications

Our Abpromise guarantee covers the use of ab139849 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
ICC/IF 1/50 - 1/100.
  • Application notesIs unsuitable for Flow Cyt,IHC-P,IP or WB.
  • Target

    • FunctionTranscription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency.
    • Involvement in diseaseDefects in SOX2 are the cause of microphthalmia syndromic type 3 (MCOPS3) [MIM:206900]. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS3 is characterized by the rare association of malformations including uni- or bilateral anophthalmia or microphthalmia, and esophageal atresia with trachoesophageal fistula.
    • Sequence similaritiesContains 1 HMG box DNA-binding domain.
    • Post-translational
      modifications
      Sumoylation inhibits binding on DNA and negatively regulates the FGF4 transactivation.
    • Cellular localizationNucleus.
    • Target information above from: UniProt accession P48431 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links
    • Alternative names
      • ANOP3 antibody
      • cb236 antibody
      • Delta EF2a antibody
      • lcc antibody
      • MCOPS3 antibody
      • MGC148683 antibody
      • MGC2413 antibody
      • RGD1565646 antibody
      • Sex determining region Y box 2 antibody
      • SOX 2 antibody
      • Sox2 antibody
      • SOX2_HUMAN antibody
      • SRY (sex determining region Y) box 2 antibody
      • SRY box containing gene 2 antibody
      • SRY related HMG box 2 antibody
      • SRY related HMG box gene 2 antibody
      • SRY-box 2 antibody
      • Transcription factor SOX 2 antibody
      • Transcription factor SOX-2 antibody
      • ysb antibody
      see all

    Anti-SOX2 [EPR3131] antibody (DyLight® 488) images

    • Immunofluorescence analysis of A) NCCIT (positive control) and B) HeLa (negative control) cells labelling SOX2 with ab139849 at 1/50.

    References for Anti-SOX2 [EPR3131] antibody (DyLight® 488) (ab139849)

    ab139849 has not yet been referenced specifically in any publications.

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