DomainThe HSR domain is important for the nuclear body targeting as well as for the dimerization. Contains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is required for interaction with chromoshadow domains. This motif requires additional residues -7, -6, +4 and +5 of the central Val which contact the chromoshadow domain.
Post-translational modificationsSumoylated. Sumoylation depends on a functional nuclear localization signal but is not necessary for nuclear import or nuclear body targeting.
Cellular localizationNucleus > PML body. Found in the nuclear body, also known as nuclear domain 10 (ND10), PML oncogenic domain (POD), nuclear dots (ND) and KR body. The nuclear body is a nucleoplasmic structure of punctate shape, which varies in size and number. Induction by interferon and may be cell cycle stages modulate the subnuclear localization of the isoforms.
Western blot against tagged recombinant protein immunogen using ab58206 SP100 antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa
References for Anti-SP100 antibody (ab58206)
This product has been referenced in:
Schmeisser H et al. Identification of alpha interferon-induced genes associated with antiviral activity in Daudi cells and characterization of IFIT3 as a novel antiviral gene. J Virol84:10671-80 (2010).
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