Overview

  • Product nameAnti-SP110 antibody
    See all SP110 primary antibodies
  • Description
    Goat polyclonal to SP110
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to internal sequence amino acids of Human SP110.

  • Positive control
    • Human spleen and tonsil tissues.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab111093 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 3.75 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • FunctionTranscription factor. May be a nuclear hormone receptor coactivator. Enhances transcription of genes with retinoic acid response elements (RARE).
  • Tissue specificityHighly expressed in peripheral blood leukocytes and spleen. Detected at intermediate levels in thymus, prostate, testis, ovary, small intestine and colon, and at low levels in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
  • Involvement in diseaseDefects in SP110 are the cause of hepatic venoocclusive disease with immunodeficiency (VODI) [MIM:235550]. VODI is an autosomal recessive primary immunodeficiency associated with hepatic vascular occlusion and fibrosis. The immunodeficiency is characterized by severe hypogammaglobulinemia, combined T and B cell immunodeficiency, absent lymph node germinal centers, and absent tissue plasma cells.
  • Sequence similaritiesContains 1 bromo domain.
    Contains 1 HSR domain.
    Contains 1 PHD-type zinc finger.
    Contains 1 SAND domain.
  • Post-translational
    modifications
    Phosphorylated (isoform 2).
  • Cellular localizationNucleus. Found in the nuclear body.
  • Information by UniProt
  • Database links
  • Alternative names
    • FLJ22835 antibody
    • IFI 41 antibody
    • IFI 75 antibody
    • IFI41 antibody
    • IFI75 antibody
    • Interferon induced protein 41 30kD antibody
    • Interferon induced protein 41 antibody
    • Interferon induced protein 41/75 antibody
    • Interferon induced protein 75 52kD antibody
    • Interferon induced protein 75 antibody
    • Interferon-induced protein 41/75 antibody
    • IPR 1 antibody
    • IPR1 antibody
    • Phosphoprotein 41 antibody
    • Phosphoprotein 75 antibody
    • SP 110 antibody
    • SP110 antibody
    • Sp110 nuclear body protein antibody
    • SP110_HUMAN antibody
    • Speckled 110 kDa antibody
    • Transcriptional coactivator Sp110 antibody
    • VODI antibody
    see all

Anti-SP110 antibody images

  • ab111093, at 3.75µg/ml, staining SP110 in formalin-fixed, paraffin-embedded Human Spleen tissue by Immunohistochemistry.
  • ab111093, at 3.75µg/ml, staining SP110 in formalin-fixed, paraffin-embedded Human Tonsil tissue by Immunohistochemistry.

References for Anti-SP110 antibody (ab111093)

ab111093 has not yet been referenced specifically in any publications.

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