Overview

  • Product name
  • Description
    Mouse polyclonal to SP110
  • Host species
    Mouse
  • Tested applications
    Suitable for: WB, IHC-P, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Gorilla, Orangutan
  • Immunogen

    Recombinant full length protein, corresponding to amino acids 1-547 of Isoform 5 of Human SP110 (Q9HB58-5).

  • Positive control
    • Human spleen lysate, SP110 transfected 293T cell line lysate, Human kidney tissue, HepG2 cells

Properties

Applications

Our Abpromise guarantee covers the use of ab168401 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 68 kDa.
IHC-P Use a concentration of 3 µg/ml.
ICC/IF Use a concentration of 10 µg/ml.

Target

  • Function
    Transcription factor. May be a nuclear hormone receptor coactivator. Enhances transcription of genes with retinoic acid response elements (RARE).
  • Tissue specificity
    Highly expressed in peripheral blood leukocytes and spleen. Detected at intermediate levels in thymus, prostate, testis, ovary, small intestine and colon, and at low levels in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
  • Involvement in disease
    Defects in SP110 are the cause of hepatic venoocclusive disease with immunodeficiency (VODI) [MIM:235550]. VODI is an autosomal recessive primary immunodeficiency associated with hepatic vascular occlusion and fibrosis. The immunodeficiency is characterized by severe hypogammaglobulinemia, combined T and B cell immunodeficiency, absent lymph node germinal centers, and absent tissue plasma cells.
  • Sequence similarities
    Contains 1 bromo domain.
    Contains 1 HSR domain.
    Contains 1 PHD-type zinc finger.
    Contains 1 SAND domain.
  • Post-translational
    modifications
    Phosphorylated (isoform 2).
  • Cellular localization
    Nucleus. Found in the nuclear body.
  • Information by UniProt
  • Database links
  • Alternative names
    • FLJ22835 antibody
    • IFI 41 antibody
    • IFI 75 antibody
    • IFI41 antibody
    • IFI75 antibody
    • Interferon induced protein 41 30kD antibody
    • Interferon induced protein 41 antibody
    • Interferon induced protein 41/75 antibody
    • Interferon induced protein 75 52kD antibody
    • Interferon induced protein 75 antibody
    • Interferon-induced protein 41/75 antibody
    • IPR 1 antibody
    • IPR1 antibody
    • Phosphoprotein 41 antibody
    • Phosphoprotein 75 antibody
    • SP 110 antibody
    • SP110 antibody
    • Sp110 nuclear body protein antibody
    • SP110_HUMAN antibody
    • Speckled 110 kDa antibody
    • Transcriptional coactivator Sp110 antibody
    • VODI antibody
    see all

Images

  • Anti-SP110 antibody (ab168401) at 1/1 dilution + Human spleen lysate at 50 µg

    Predicted band size: 68 kDa

  • All lanes : Anti-SP110 antibody (ab168401) at 1 µg/ml

    Lane 1 : SP110 transfected 293T cell line lysate
    Lane 2 : Non-transfected 293T cell line lysate

    Predicted band size: 68 kDa

  • Immunohistochemical analysis of paraffin embedded Human kidney tissue labeling SP110 with ab168401 antibody at 3 µg/ml.
  • Immunofluorescent analysis of HepG2 cells labeling SP110 with ab168401 at 10 µg/ml.

References

ab168401 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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