• Product name
  • Description
    Rabbit polyclonal to SP110
  • Specificity
    This product recognizes isoforms a, b and c.
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    A 16 amino acid synthetic peptide derived from near the amino terminus of human SP1101. (GenBank accession no. NP_004501, isoform b).

  • Positive control
    • SW480 cell lysate



Our Abpromise guarantee covers the use of ab67221 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notes
    WB: Use at a concentration of 1 - 2 µg/ml. Detects a band of approximately 80-95 kDa (predicted molecular weight of longest isoform: 79 kDa).

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Transcription factor. May be a nuclear hormone receptor coactivator. Enhances transcription of genes with retinoic acid response elements (RARE).
    • Tissue specificity
      Highly expressed in peripheral blood leukocytes and spleen. Detected at intermediate levels in thymus, prostate, testis, ovary, small intestine and colon, and at low levels in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
    • Involvement in disease
      Defects in SP110 are the cause of hepatic venoocclusive disease with immunodeficiency (VODI) [MIM:235550]. VODI is an autosomal recessive primary immunodeficiency associated with hepatic vascular occlusion and fibrosis. The immunodeficiency is characterized by severe hypogammaglobulinemia, combined T and B cell immunodeficiency, absent lymph node germinal centers, and absent tissue plasma cells.
    • Sequence similarities
      Contains 1 bromo domain.
      Contains 1 HSR domain.
      Contains 1 PHD-type zinc finger.
      Contains 1 SAND domain.
    • Post-translational
      Phosphorylated (isoform 2).
    • Cellular localization
      Nucleus. Found in the nuclear body.
    • Information by UniProt
    • Database links
    • Alternative names
      • FLJ22835 antibody
      • IFI 41 antibody
      • IFI 75 antibody
      • IFI41 antibody
      • IFI75 antibody
      • Interferon induced protein 41 30kD antibody
      • Interferon induced protein 41 antibody
      • Interferon induced protein 41/75 antibody
      • Interferon induced protein 75 52kD antibody
      • Interferon induced protein 75 antibody
      • Interferon-induced protein 41/75 antibody
      • IPR 1 antibody
      • IPR1 antibody
      • Phosphoprotein 41 antibody
      • Phosphoprotein 75 antibody
      • SP 110 antibody
      • SP110 antibody
      • Sp110 nuclear body protein antibody
      • SP110_HUMAN antibody
      • Speckled 110 kDa antibody
      • Transcriptional coactivator Sp110 antibody
      • VODI antibody
      see all

    Anti-SP110 antibody images

    • Lane 1 : Anti-SP110 antibody (ab67221) at 1 µg/ml
      Lane 2 : Anti-SP110 antibody (ab67221) at 2 µg/ml

      Lane 1 : SW480 cell lysate
      Lane 2 : SW480 cell lysate

      Lysates/proteins at 15 µg per lane.

      Anti rabbit secondary antibody

      Predicted band size : 79 kDa
      Observed band size : 80-95 kDa (why is the actual band size different from the predicted?)

    References for Anti-SP110 antibody (ab67221)

    This product has been referenced in:
    • Molzan M  et al. Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling. Mol Cell Biol 30:4698-711 (2010). Read more (PubMed: 20679480) »

    See 1 Publication for this product

    Product Wall

    Thank you for your enquiry. This product, ab67220 can detect isoform b, and c. Meanwhile, ab67221 can detect isoforms a, b,c.


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