Overview

  • Product name
    SP600125
  • Description
    JNK inhibitor
  • Biological description
    Potent and selective JNK1, -2, and -3 inhibitor (IC50 = 0.11 μM). SP600125 is a reversible ATP-competitive inhibitor with >20-fold selectivity over a range of kinases. It dose-dependently inhibits the phosphorylation of c-Jun and the expression of inflammatory genes COX-2, IL-2, IFNγ and TNFα. Neuroprotective in vivo.
  • Purity
    > 99%

Properties

References

This product has been referenced in:
  • Guan QH  et al. Neuroprotection against ischemic brain injury by SP600125 via suppressing the extrinsic and intrinsic pathways of apoptosis. Brain Res 1092:36-46 (2006). Read more (PubMed: 16674927) »
  • Heo YS  et al. Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125. EMBO J 23:2185-95 (2004). Read more (PubMed: 15141161) »
  • Bennett BL  et al. SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase. Proc Natl Acad Sci U S A 98:13681-6 (2001). Read more (PubMed: 11717429) »

See all 7 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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