Anti-Sp7 / Osterix antibody - ChIP Grade (ab22552)

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ab22552 has been referenced in 52 publications.

  • Pang J  et al. ACVR1-Fc suppresses BMP signaling and chondro-osseous differentiation in an in vitro model of Fibrodysplasia ossificans progressiva. Bone 92:29-36 (2016). WB ; Human . PubMed: 27492611
  • Bian Q  et al. Excessive Activation of TGFß by Spinal Instability Causes Vertebral Endplate Sclerosis. Sci Rep 6:27093 (2016). IHC-P ; Mouse . PubMed: 27256073
  • Qu X  et al. MiR-132-3p Regulates the Osteogenic Differentiation of Thoracic Ligamentum Flavum Cells by Inhibiting Multiple Osteogenesis-Related Genes. Int J Mol Sci 17:N/A (2016). WB ; Human . PubMed: 27556448
  • Xu J  et al. Human fetal mesenchymal stem cell secretome enhances bone consolidation in distraction osteogenesis. Stem Cell Res Ther 7:134 (2016). PubMed: 27612565
  • Alotaibi MK  et al. Smad2 overexpression induces alveolar bone loss and up regulates TNF-a, and RANKL. Arch Oral Biol 71:38-45 (2016). PubMed: 27421098
  • Chen J  et al. The influence of the sensory neurotransmitter calcitonin gene-related peptide on bone marrow mesenchymal stem cells from ovariectomized rats. J Bone Miner Metab N/A:N/A (2016). PubMed: 27623790
  • Takimoto A  et al. Scleraxis and osterix antagonistically regulate tensile force-responsive remodeling of the periodontal ligament and alveolar bone. Development 142:787-96 (2015). IHC-Fr ; Mouse . PubMed: 25670797
  • Xu X  et al. Aberrant Activation of TGF-ß in Subchondral Bone at the Onset of Rheumatoid Arthritis Joint Destruction. J Bone Miner Res 30:2033-43 (2015). IHC . PubMed: 25967237
  • Remoli C  et al. Osteoblast-specific expression of the fibrous dysplasia (FD)-causing mutation Gsa(R201C) produces a high bone mass phenotype but does not reproduce FD in the mouse. J Bone Miner Res 30:1030-43 (2015). PubMed: 25487351
  • Kawao N  et al. The Tissue Fibrinolytic System Contributes to the Induction of Macrophage Function and CCL3 during Bone Repair in Mice. PLoS One 10:e0123982 (2015). Mouse . PubMed: 25893677
  • Huang B  et al. mTORC1 Prevents Preosteoblast Differentiation through the Notch Signaling Pathway. PLoS Genet 11:e1005426 (2015). IHC ; Mouse . PubMed: 26241748
  • Chen F  et al. Nuclear Export of Smads by RanBP3L Regulates Bone Morphogenetic Protein Signaling and Mesenchymal Stem Cell Differentiation. Mol Cell Biol 35:1700-11 (2015). PubMed: 25755279
  • Artigas N  et al. Mitogen-activated protein kinase (MAPK)-regulated interactions between Osterix and Runx2 are critical for the transcriptional osteogenic program. J Biol Chem 289:27105-17 (2014). ICC/IF ; Human . PubMed: 25122769
  • Cheng S  et al. Conditional disruption of the prolyl hydroxylase domain-containing protein 2 (Phd2) gene defines its key role in skeletal development. J Bone Miner Res 29:2276-86 (2014). PubMed: 24753072
  • Sammarco MC  et al. Endogenous bone regeneration is dependent upon a dynamic oxygen event. J Bone Miner Res 29:2336-45 (2014). IHC ; Mouse . PubMed: 24753124
  • Lin S  et al. Constitutive nuclear expression of dentin matrix protein 1 fails to rescue the Dmp1-null phenotype. J Biol Chem 289:21533-43 (2014). PubMed: 24917674
  • Lai LP  et al. Stk11 (Lkb1) deletion in the osteoblast lineage leads to high bone turnover, increased trabecular bone density and cortical porosity. Bone 69:98-108 (2014). Mouse . PubMed: 25240456
  • Tan SH  et al. Wnts produced by Osterix-expressing osteolineage cells regulate their proliferation and differentiation. Proc Natl Acad Sci U S A 111:E5262-71 (2014). IHC-Fr ; Mouse . PubMed: 25422448
  • Bojar W  et al. Bone regeneration potential of the new chitosan-based alloplastic biomaterial. J Biomater Appl 28:1060-8 (2014). Rat . PubMed: 23796631
  • Lamoureux F  et al. Selective inhibition of BET bromodomain epigenetic signalling interferes with the bone-associated tumour vicious cycle. Nat Commun 5:3511 (2014). PubMed: 24646477
  • Wang H  et al. Polycystin-1 mediates mechanical strain-induced osteoblastic mechanoresponses via potentiation of intracellular calcium and Akt/ß-catenin pathway. PLoS One 9:e91730 (2014). Mouse . PubMed: 24618832
  • Imamura K  et al. Human immunodeficiency virus type 1 enhancer-binding protein 3 is essential for the expression of asparagine-linked glycosylation 2 in the regulation of osteoblast and chondrocyte differentiation. J Biol Chem 289:9865-79 (2014). WB . PubMed: 24563464
  • Lomashvili KA  et al. Vascular calcification is dependent on plasma levels of pyrophosphate. Kidney Int 85:1351-6 (2014). IHC (PFA fixed) ; Mouse . PubMed: 24717293
  • Chen W  et al. Cbfß deletion in mice recapitulates cleidocranial dysplasia and reveals multiple functions of Cbfß required for skeletal development. Proc Natl Acad Sci U S A 111:8482-7 (2014). Mouse . PubMed: 24850862
  • Lin RZ  et al. Human endothelial colony-forming cells serve as trophic mediators for mesenchymal stem cell engraftment via paracrine signaling. Proc Natl Acad Sci U S A 111:10137-42 (2014). PubMed: 24982174
  • Chen M  et al. Low-dose X-ray irradiation promotes osteoblast proliferation, differentiation and fracture healing. PLoS One 9:e104016 (2014). WB ; Mouse . PubMed: 25089831
  • Yang L  et al. Hypertrophic chondrocytes can become osteoblasts and osteocytes in endochondral bone formation. Proc Natl Acad Sci U S A 111:12097-102 (2014). PubMed: 25092332
  • Wu M  et al. Deletion of core-binding factor ß (Cbfß) in mesenchymal progenitor cells provides new insights into Cbfß/Runxs complex function in cartilage and bone development. Bone 65:49-59 (2014). PubMed: 24798493
  • Gámez B  et al. MicroRNA-322 (miR-322) and its target protein Tob2 modulate Osterix (Osx) mRNA stability. J Biol Chem 288:14264-75 (2013). WB ; Human . PubMed: 23564456
  • Qian H  et al. Molecular characterization of prospectively isolated multipotent mesenchymal progenitors provides new insight into the cellular identity of mesenchymal stem cells in mouse bone marrow. Mol Cell Biol 33:661-77 (2013). IHC-Fr ; Mouse . PubMed: 23184664
  • Khavandgar Z  et al. Local regulation of tooth mineralization by sphingomyelin phosphodiesterase 3. J Dent Res 92:358-64 (2013). Mouse . PubMed: 23428435
  • Gilmour PS  et al. Human stem cell osteoblastogenesis mediated by novel glycogen synthase kinase 3 inhibitors induces bone formation and a unique bone turnover biomarker profile in rats. Toxicol Appl Pharmacol 272:399-407 (2013). PubMed: 23872097
  • Barbuto R & Mitchell J Regulation of the osterix (Osx, Sp7) promoter by osterix and its inhibition by parathyroid hormone. J Mol Endocrinol 51:99-108 (2013). Mouse . PubMed: 23682129
  • Regard JB  et al. Activation of Hedgehog signaling by loss of GNAS causes heterotopic ossification. Nat Med 19:1505-12 (2013). PubMed: 24076664
  • Cheng S  et al. Haploinsufficiency of osterix in chondrocytes impairs skeletal growth in mice. Physiol Genomics 45:917-23 (2013). IHC ; Mouse . PubMed: 23943855
  • Lai LP  et al. Lkb1/Stk11 regulation of mTOR signaling controls the transition of chondrocyte fates and suppresses skeletal tumor formation. Proc Natl Acad Sci U S A 110:19450-5 (2013). PubMed: 24218567
  • Li C  et al. Disruption of LRP6 in osteoblasts blunts the bone anabolic activity of PTH. J Bone Miner Res 28:2094-108 (2013). PubMed: 23609180
  • Zhen G  et al. Inhibition of TGF-ß signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis. Nat Med 19:704-12 (2013). PubMed: 23685840
  • Pacheco M  et al. Evc works in chondrocytes and osteoblasts to regulate multiple aspects of growth plate development in the appendicular skeleton and cranial base. Bone 50:28-41 (2012). ICC/IF, IHC-P ; Mouse . PubMed: 21911092
  • Oh JH  et al. Chondrocyte-specific ablation of Osterix leads to impaired endochondral ossification. Biochem Biophys Res Commun 418:634-40 (2012). PubMed: 22290230
  • Hojo H  et al. Gli1 protein participates in Hedgehog-mediated specification of osteoblast lineage during endochondral ossification. J Biol Chem 287:17860-9 (2012). IHC-Fr ; Mouse . PubMed: 22493482
  • Xing W  et al. Ascorbic acid regulates osterix expression in osteoblasts by activation of prolyl hydroxylase and ubiquitination-mediated proteosomal degradation pathway. Physiol Genomics 43:749-57 (2011). PubMed: 21467157
  • Gabbay KH  et al. Ascorbate synthesis pathway: dual role of ascorbate in bone homeostasis. J Biol Chem 285:19510-20 (2010). IHC-FoFr ; Mouse . PubMed: 20410296
  • Ortuño MJ  et al. p38 regulates expression of osteoblast-specific genes by phosphorylation of osterix. J Biol Chem 285:31985-94 (2010). WB, ICC/IF, ChIP ; Human, Mouse . PubMed: 20682789
  • Mirando AJ  et al. ß-catenin/cyclin D1 mediated development of suture mesenchyme in calvarial morphogenesis. BMC Dev Biol 10:116 (2010). IHC-FoFr ; Mouse . PubMed: 21108844
  • Medici D  et al. Conversion of vascular endothelial cells into multipotent stem-like cells. Nat Med 16:1400-6 (2010). PubMed: 21102460
  • Xie Y  et al. Detection of functional haematopoietic stem cell niche using real-time imaging. Nature 457:97-101 (2009). IHC-P ; Mouse . PubMed: 19052548
  • Miller JD  et al. Lowering plasma cholesterol levels halts progression of aortic valve disease in mice. Circulation 119:2693-701 (2009). ICC/IF ; Mouse . PubMed: 19433756
  • Hsiao EC  et al. Osteoblast expression of an engineered Gs-coupled receptor dramatically increases bone mass. Proc Natl Acad Sci U S A 105:1209-14 (2008). IHC-P ; Mouse . PubMed: 18212126
  • Hosoya A  et al. Alveolar bone regeneration of subcutaneously transplanted rat molar. Bone 42:350-7 (2008). PubMed: 18032126
  • Xing W  et al. Nuclear factor-E2-related factor-1 mediates ascorbic acid induction of osterix expression via interaction with antioxidant-responsive element in bone cells. J Biol Chem 282:22052-61 (2007). WB ; Mouse . PubMed: 17510056
  • Zhao C  et al. Immunohistochemical study of hard tissue formation in the rat pulp cavity after tooth replantation. Arch Oral Biol 52:945-53 (2007). IHC-P ; Rat . PubMed: 17570339

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