Overview

  • Product nameAnti-SPARC antibody
    See all SPARC primary antibodies
  • Description
    Rabbit polyclonal to SPARC
  • SpecificityThere were no cross reactivities obtained with human Osteopontin, and human Bone Sialoprotein.
  • Tested applicationsSuitable for: ELISAmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Chicken, Cow, Xenopus laevis
  • Immunogen

    Synthetic peptide:

    TCDLDNDKYIALDEW

    , corresponding to amino acids 272-286 of Human SPARC.

Properties

Applications

Our Abpromise guarantee covers the use of ab14177 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/3000.

Target

  • FunctionAppears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.
  • Sequence similaritiesBelongs to the SPARC family.
    Contains 1 EF-hand domain.
    Contains 1 follistatin-like domain.
    Contains 1 Kazal-like domain.
  • Developmental stageExpressed at high levels in tissues undergoing morphogenesis, remodeling and wound repair.
  • Cellular localizationSecreted > extracellular space > extracellular matrix > basement membrane. In or around the basement membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • AA517111 antibody
    • Basement membrane protein 40 antibody
    • Basement-membrane protein 40 antibody
    • BM 40 antibody
    • BM-40 antibody
    • BM40 antibody
    • Cysteine rich protein antibody
    • hm:zeh0062 antibody
    • MGC128090 antibody
    • OI17 antibody
    • ON antibody
    • Osteonectin antibody
    • Secreted acidic cystein rich glycoprotein antibody
    • Secreted protein acidic and rich in cysteine antibody
    • Secreted protein acidic cysteine rich (osteonectin) antibody
    • Secreted protein acidic cysteine rich antibody
    • SPARC antibody
    • SPRC antibody
    • SPRC_HUMAN antibody
    see all

References for Anti-SPARC antibody (ab14177)

ab14177 has not yet been referenced specifically in any publications.

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