Overview

  • Product nameAnti-SPARC antibody
    See all SPARC primary antibodies
  • Description
    Mouse monoclonal to SPARC
  • SpecificityRecognises bone SPARC and platelet osteonectin
  • Tested applicationsSuitable for: WB, ELISA, RIAmore details
  • Species reactivity
    Reacts with: Rat, Cow, Human
  • Immunogen

    Full length native purified Human SPARC

  • EpitopeFirst half of the N-terminus of the protein excluding the first 28 amino acids.

Properties

Applications

Our Abpromise guarantee covers the use of ab61383 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent concentration. Predicted molecular weight: 35 kDa.
ELISA Use at an assay dependent dilution.
RIA Use at an assay dependent dilution.

Target

  • FunctionAppears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.
  • Sequence similaritiesBelongs to the SPARC family.
    Contains 1 EF-hand domain.
    Contains 1 follistatin-like domain.
    Contains 1 Kazal-like domain.
  • Developmental stageExpressed at high levels in tissues undergoing morphogenesis, remodeling and wound repair.
  • Cellular localizationSecreted > extracellular space > extracellular matrix > basement membrane. In or around the basement membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • AA517111 antibody
    • Basement membrane protein 40 antibody
    • Basement-membrane protein 40 antibody
    • BM 40 antibody
    • BM-40 antibody
    • BM40 antibody
    • Cysteine rich protein antibody
    • hm:zeh0062 antibody
    • MGC128090 antibody
    • OI17 antibody
    • ON antibody
    • Osteonectin antibody
    • Secreted acidic cystein rich glycoprotein antibody
    • Secreted protein acidic and rich in cysteine antibody
    • Secreted protein acidic cysteine rich (osteonectin) antibody
    • Secreted protein acidic cysteine rich antibody
    • SPARC antibody
    • SPRC antibody
    • SPRC_HUMAN antibody
    see all

References for Anti-SPARC antibody (ab61383)

ab61383 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your reply.


After checking our records, I have found epitope information for both of these antibodies:


For ab13418: epitope includes the gamma-carboxylated residue at position 17
For ab61383: epitope i...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"