Overview

  • Product nameAnti-SPDEF antibody
    See all SPDEF primary antibodies
  • Description
    Rabbit polyclonal to SPDEF
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide derived from the internal region of human SPDEF.

  • Positive control
    • LNCAP prostate carcinoma cell lysates.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab53881 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
ELISA
  • Application notesPeptide ELISA: Use at a concentration of 0.1 - 1 µg/ml.
    WB: Use at a concentration of 1 - 3 µg/ml. Detects a band of approximately 37 kDa (predicted molecular weight: 37 kDa). A weak band at 55 kDa is also detected which may be due to the glycosylated form of PDEF.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionMay function as an androgen-independent transactivator of the prostate-specific antigen (PSA) promoter. Binds to 5'-GGAT-3' DNA sequences. May play a role in the regulation of the prostate gland and/or prostate cancer development. Acts as a transcriptional activator for SERPINB5 promoter.
    • Tissue specificityExpressed in a very restricted set of primarily hormone-regulated epithelial tissues with particularly high expression in the prostate gland. Significantly lower expression is seen in other hormone regulated tissues such as mammary gland, salivary gland, and ovary. Expressed in prostate carcinoma cells.
    • Sequence similaritiesBelongs to the ETS family.
      Contains 1 ETS DNA-binding domain.
      Contains 1 PNT (pointed) domain.
    • Cellular localizationNucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • bA375E1.3 antibody
      • PDEF antibody
      • Prostate derived Ets factor antibody
      • PROSTATE EPITHELIUM SPECIFIC ETS TRANSCRIPTION FACTOR antibody
      • Prostate epithelium-specific Ets transcription factor antibody
      • Prostate specific Ets antibody
      • Prostate-derived Ets factor antibody
      • Prostate-specific Ets antibody
      • PSE antibody
      • RP11-375E1__A.3 antibody
      • SAM POINTED DOMAIN CONTAINING ETS TRANSCRIPTION FACTOR antibody
      • SAM pointed domain-containing Ets transcription factor antibody
      • Spdef antibody
      • SPDEF_HUMAN antibody
      see all

    References for Anti-SPDEF antibody (ab53881)

    This product has been referenced in:
    • Hasnain SZ  et al. Changes in the mucosal barrier during acute and chronic Trichuris muris infection. Parasite Immunol 33:45-55 (2011). IHC ; Mouse . Read more (PubMed: 21155842) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"