Overview

  • Product nameAnti-SPDEF antibody
    See all SPDEF primary antibodies
  • Description
    Mouse monoclonal to SPDEF
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment, corresponding to amino acids 92-201 of Human SPDEF

Properties

Applications

Our Abpromise guarantee covers the use of ab57042 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 5 µg/ml. This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

Target

  • FunctionMay function as an androgen-independent transactivator of the prostate-specific antigen (PSA) promoter. Binds to 5'-GGAT-3' DNA sequences. May play a role in the regulation of the prostate gland and/or prostate cancer development. Acts as a transcriptional activator for SERPINB5 promoter.
  • Tissue specificityExpressed in a very restricted set of primarily hormone-regulated epithelial tissues with particularly high expression in the prostate gland. Significantly lower expression is seen in other hormone regulated tissues such as mammary gland, salivary gland, and ovary. Expressed in prostate carcinoma cells.
  • Sequence similaritiesBelongs to the ETS family.
    Contains 1 ETS DNA-binding domain.
    Contains 1 PNT (pointed) domain.
  • Cellular localizationNucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • bA375E1.3 antibody
    • PDEF antibody
    • Prostate derived Ets factor antibody
    • PROSTATE EPITHELIUM SPECIFIC ETS TRANSCRIPTION FACTOR antibody
    • Prostate epithelium-specific Ets transcription factor antibody
    • Prostate specific Ets antibody
    • Prostate-derived Ets factor antibody
    • Prostate-specific Ets antibody
    • PSE antibody
    • RP11-375E1__A.3 antibody
    • SAM POINTED DOMAIN CONTAINING ETS TRANSCRIPTION FACTOR antibody
    • SAM pointed domain-containing Ets transcription factor antibody
    • Spdef antibody
    • SPDEF_HUMAN antibody
    see all

Anti-SPDEF antibody images

  • Western blot against tagged recombinant protein immunogen using ab57042 SPDEF antibody at 1ug/ml. Predicted band size of immunogen is 38 kDa

References for Anti-SPDEF antibody (ab57042)

This product has been referenced in:
  • Yadav UC  et al. Aldose reductase inhibition prevents metaplasia of airway epithelial cells. PLoS One 5:e14440 (2010). WB ; Human . Read more (PubMed: 21203431) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"