Overview

  • Product name
    SPEN peptide (1503-1517)

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      C-DSEGKMDDKKEDHKE
    • Amino acids
      1503 to 1517

Specifications

Our Abpromise guarantee covers the use of ab45877 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

General Info

  • Alternative names
    • MINT
    • Nuclear receptor transcription cofactor
    • RBM15C
    • SHARP
    • SPEN homolog
    • Spen homolog transcriptional regulator
    see all
  • Relevance
    SPEN is an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. It is a negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. SPEN blocks the differentiation of precursor B-cells into marginal zone B-cells. It probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. SPEN may bind both to DNA and RNA.
  • Cellular localization
    Nuclear. Associates with chromatin.

References for SPEN peptide (1503-1517) (ab45877)

ab45877 has not yet been referenced specifically in any publications.

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