Overview

  • Product name
  • Description
    Goat polyclonal to SPFH2
  • Specificity
    This antibody is expected to recognise isoform 1 (NP_009106) only.
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Rat
  • Immunogen

    Synthetic peptide:

    EDEPLETATKEN

    , corresponding to C terminal amino acids 328-339 of Human SPFH2

  • Positive control
    • Human breast lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab36123 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.3 - 1 µg/ml. Detects a band of approximately 43 kDa (predicted molecular weight: 38 kDa). The observed molecular weight corresponds to earlier findings in literature with different antibodies (Pearce et al, J Biol Chem. 2007 Jul 13;282(28):20104-15.; PMID: 17502376).

Target

  • Function
    Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Also involved in ITPR1 degradation by the ERAD pathway.
  • Tissue specificity
    Ubiquitous.
  • Sequence similarities
    Belongs to the band 7/mec-2 family.
  • Cellular localization
    Endoplasmic reticulum membrane. Associated with lipid raft-like domains of the endoplasmic reticulum membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • C8orf2 antibody
    • Chromosome 8 open reading frame 2 antibody
    • Endoplasmic reticulum lipid raft associated protein 2 antibody
    • Endoplasmic reticulum lipid raft-associated protein 2 antibody
    • ER lipid raft associated 2 antibody
    • ERLIN 2 antibody
    • Erlin-2 antibody
    • ERLIN2 antibody
    • ERLN2_HUMAN antibody
    • HGNC:1356 antibody
    • MGC87072 antibody
    • NET32 antibody
    • SPFH 2 antibody
    • SPFH domain containing protein 2 antibody
    • SPFH domain family member 2 antibody
    • SPFH domain-containing protein 2 antibody
    • SPFH2 antibody
    • SPG18 antibody
    • Stomatin prohibitin flotillin HflC/K domain containing protein 2 antibody
    • Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2 antibody
    see all

Images

References

This product has been referenced in:
  • Sánchez-Quiles V  et al. Prohibitin deficiency blocks proliferation and induces apoptosis in human hepatoma cells: molecular mechanisms and functional implications. Proteomics 10:1609-20 (2010). WB ; Human . Read more (PubMed: 20186755) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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