Overview

  • Product nameAnti-SPG11 antibody
  • Description
    Mouse polyclonal to SPG11
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length human SPG11 protein (AAH24161.1)

  • Positive control
    • SPG11 transfected 293T cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab69164 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Detects a band of approximately 44 kDa (predicted molecular weight: 49 kDa). (Isoform 1, 279 kDa).

Target

  • Tissue specificityExpressed in all structures of brain, with a high expression in cerebellum.
  • Involvement in diseaseDefects in SPG11 are the cause of spastic paraplegia autosomal recessive type 11 (SPG11) [MIM:604360]. Spastic paraplegia is a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body.
  • Post-translational
    modifications
    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localizationMembrane. Cytoplasm > cytosol. Nucleus. Mainly cytoplasmic.
  • Information by UniProt
  • Database links
  • Alternative names
    • Colorectal carcinoma associated protein antibody
    • Colorectal carcinoma-associated protein antibody
    • DKFZp762B1512 antibody
    • FLJ21439 antibody
    • KIAA1840 antibody
    • Spastic paraplegia 11 (autosomal recessive) antibody
    • Spastic paraplegia 11 antibody
    • Spastic paraplegia 11 protein antibody
    • Spatacsin antibody
    • SPG 11 antibody
    • Spg11 antibody
    • SPTCS_HUMAN antibody
    see all

Anti-SPG11 antibody images

  • All lanes : Anti-SPG11 antibody (ab69164) at 1/500 dilution

    Lane 1 : SPG11 transfected 293T cell lysate
    Lane 2 : Non-transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

    Predicted band size : 49 kDa
    Observed band size : 44 kDa (why is the actual band size different from the predicted?)

References for Anti-SPG11 antibody (ab69164)

ab69164 has not yet been referenced specifically in any publications.

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