This fast track antibody is not yet fully characterized. It is subject to these terms and conditions

Overview

  • Product name
    Anti-Spindle E antibody
  • Description
    Rabbit polyclonal to Spindle E

    This product is a fast track antibody. It has been affinity purified and shows high titre values against the immunizing peptide by ELISA. Read the terms of use »

  • Species reactivity

    Predicted to work with: Drosophila melanogaster
  • Immunogen

    Synthetic peptide derived from residues 1400 to the C terminus of Drosophila melanogaster Spindle E.

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Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer
    Preservative: 0.02% Sodium Azide
    Constituents: 1% BSA, PBS, pH 7.4
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

  • Application notes
    Tested in peptide ELISA.
    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Relevance
      Spindle-E or spn-E encodes a putative DEAD-box helicase, spn-E, which has been shown to be required for RNAi in Drosophila oocytes. Mutations in the aubergine and spindle-E genes, members of the Argonaute and RNA helicase gene families, respectively, impair silencing by eliminating the short Su(Ste) RNA, but have no effect on microRNA production Mutations in Piwi, Aubergine, or Spindle-E, which encode RNAi components result in reduction of H3 Lys9 methylation and delocalization of HP1 and HP2. RNAi is activated during Drosophila oocyte maturation in a manner dependent on aubergine (the Argonaute protein) and spindle-E.
    • Cellular localization
      Nuclear
    • Database links
      • Alternative names
        • CG3158 antibody
        • CG3158 PA antibody
        • female sterile(3)homeless antibody
        • Fs(1)hls antibody
        • Hls antibody
        • homeless antibody
        • Spindle E CG3158 PA antibody
        • SpindleE antibody
        • Spn E antibody
        • Spn E/hls antibody
        • SpnE antibody
        see all

      References

      ab5204 has not yet been referenced specifically in any publications.

      Customer reviews and Q&As

      Thank you for your enquiry. Spindle-E is part of the RNA interference machinery and therefore a nuclear protein. You may wish to consult the reference: Heterochromatic silencing and HP1 localization in Drosophila are dependent on the RNAi machi...

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      Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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