Overview

  • Product name
  • Description
    Mouse polyclonal to SPO11
  • Host species
    Mouse
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length protein, corresponding to amino acids 1-358 of Human SPO11 (NP_937998).

  • Positive control
    • SPO11 transfected 293T cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab168262 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 40 kDa.

Target

  • Function
    Required for meiotic recombination. Mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination (By similarity). Essential for the phosphorylation of SMC3, HORMAD1 and HORMAD2.
  • Tissue specificity
    Highly expressed in testis.
  • Sequence similarities
    Belongs to the TOP6A family.
  • Cellular localization
    Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • Cancer/testis antigen 35 antibody
    • CT35 antibody
    • Meiotic recombination protein SPO 11 antibody
    • Meiotic recombination protein SPO11 antibody
    • MGC39953 antibody
    • SPATA43 antibody
    • Spermatogenesis associated 43 antibody
    • SPO 11 antibody
    • SPO11 antibody
    • SPO11 meiotic protein covalently bound to DSB antibody
    • SPO11 meiotic protein covalently bound to DSB homolog antibody
    • SPO11 meiotic protein covalently bound to DSB like antibody
    • SPO11_HUMAN antibody
    • TOPVIA antibody
    see all

Images

  • All lanes : Anti-SPO11 antibody (ab168262) at 1 µg/ml

    Lane 1 : SPO11 transfected 293T cell lysate
    Lane 2 : Non transfected 293T cell lysate

    Lysates/proteins at 15 µl per lane.

    Secondary
    All lanes : Goat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution

    Developed using the ECL technique.

    Predicted band size: 40 kDa

References

ab168262 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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