Overview

  • Product nameAnti-SPR antibody
    See all SPR primary antibodies
  • Description
    Rabbit polyclonal to SPR
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide conjugated to KLH, between C terminal amino acids 232-261 of Human SPR.

  • Positive control
    • Mouse liver tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab103353 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/1000. Predicted molecular weight: 28 kDa.

Target

  • FunctionCatalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin.
  • Involvement in diseaseDefects in SPR are the cause of dystonia DOPA-responsive due to sepiapterin reductase deficiency (DRDSPRD) [MIM:612716]. In the majority of cases, patients manifest progressive psychomotor retardation, dystonia and spasticity. Cognitive anomalies are also often present. The disease is due to severe dopamine and serotonin deficiencies in the central nervous system caused by a defect in BH4 synthesis. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures.
  • Sequence similaritiesBelongs to the sepiapterin reductase family.
  • Post-translational
    modifications
    In vitro phosphorylation of Ser-213 by CaMK2 does not change kinetic parameters.
  • Cellular localizationCytoplasm.
  • Information by UniProt
  • Database links
  • Alternative names
    • OTTHUMP00000160199 antibody
    • SDR38C1 antibody
    • Sepiapterin reductase (7,8 dihydrobiopterin:NADP+ oxidoreductase) antibody
    • Sepiapterin reductase antibody
    • Short chain dehydrogenase/reductase family 38C, member 1 antibody
    • SPR antibody
    • SPRE_HUMAN antibody
    see all

Anti-SPR antibody images

  • Anti-SPR antibody (ab103353) at 1/1000 dilution + Mouse liver tissue lysate at 35 µg

    Secondary
    Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution

    Predicted band size : 28 kDa

    Blocking/Dilution buffer: 5% NFDM/TBST.

References for Anti-SPR antibody (ab103353)

ab103353 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"