Overview

  • Product nameAnti-SPR antibody
    See all SPR primary antibodies
  • Description
    Rabbit polyclonal to SPR
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant protein fragment contain a sequence corresponding to a region within amino acids 65 and 253 of Human SPR (Uniprot ID: P35270).

  • Positive control
    • 293T, H1299, HeLa, HepG2 and A431 cell lysates

Properties

Applications

Our Abpromise guarantee covers the use of ab96027 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 28 kDa.

Target

  • FunctionCatalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin.
  • Involvement in diseaseDefects in SPR are the cause of dystonia DOPA-responsive due to sepiapterin reductase deficiency (DRDSPRD) [MIM:612716]. In the majority of cases, patients manifest progressive psychomotor retardation, dystonia and spasticity. Cognitive anomalies are also often present. The disease is due to severe dopamine and serotonin deficiencies in the central nervous system caused by a defect in BH4 synthesis. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures.
  • Sequence similaritiesBelongs to the sepiapterin reductase family.
  • Post-translational
    modifications
    In vitro phosphorylation of Ser-213 by CaMK2 does not change kinetic parameters.
  • Cellular localizationCytoplasm.
  • Information by UniProt
  • Database links
  • Alternative names
    • OTTHUMP00000160199 antibody
    • SDR38C1 antibody
    • Sepiapterin reductase (7,8 dihydrobiopterin:NADP+ oxidoreductase) antibody
    • Sepiapterin reductase antibody
    • Short chain dehydrogenase/reductase family 38C, member 1 antibody
    • SPR antibody
    • SPRE_HUMAN antibody
    see all

Anti-SPR antibody images

  • Anti-SPR antibody (ab96027) at 1/1000 dilution + A431 whole cell lysate at 30 µg

    Predicted band size : 28 kDa

References for Anti-SPR antibody (ab96027)

ab96027 has not yet been referenced specifically in any publications.

Product Wall

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