Overview

  • Product name
    SR-8278
  • Description
    REV-ERBα antagonist
  • Biological description
    REV-ERBα antagonist (EC50 = 470 nM, REV-ERBα transcriptional repression activity). Stimulates the expression of gluconeogenesis genes G6Pase and PEPCK.

Properties

  • Chemical name
    Ethyl 2-(5-methylsulfanylthiophene-2-carbonyl)-3,4-dihydro-1H-isoquinoline-3-carboxylate
  • Molecular weight
    361.48
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C18H19NO3S2
  • CAS Number
    1254944-66-5
  • PubChem identifier
    53393127
  • Storage instructions
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in ethanol to 25 mM and in DMSO to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    CCOC(=O)C1CC2=CC=CC=C2CN1C(=O)C3=CC=C(S3)SC
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:
  • Isayama K  et al. REV-ERBa inhibits the PTGS2 expression in bovine uterus endometrium stromal and epithelial cells exposed to ovarian steroids. J Reprod Dev 60:362-70 (2014). Read more (PubMed: 25007867) »
  • Vieira E  et al. Involvement of the clock gene Rev-erb alpha in the regulation of glucagon secretion in pancreatic alpha-cells. PLoS One 8:e69939 (2013). Read more (PubMed: 23936124) »
  • Kojetin D  et al. Identification of SR8278, a synthetic antagonist of the nuclear heme receptor REV-ERB. ACS Chem Biol 6:131-4 (2011). Read more (PubMed: 21043485) »

See 0 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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