• NatureSynthetic

Associated products


Our Abpromise guarantee covers the use of ab4915 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications


  • FormLiquid
  • Additional notes

    This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and AIB 1, catalog ab2831. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~ 70-fold) for competitive inhibition of antibody-protein binding reactions.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

General Info

  • Alternative names
    • ACTR
    • AIB 1
    • AIB-1
    • AIB1
    • Amplified in breast cancer 1
    • Amplified in breast cancer 1 protein
    • bHLHe42
    • CAGH 16
    • CAGH16
    • CBP interacting protein
    • CBP-interacting protein
    • Class E basic helix-loop-helix protein 42
    • CTG 26
    • CTG26
    • KAT13B / AIB1
    • MGC141848
    • NCOA 3
    • NCoA-3
    • Ncoa3
    • Nuclear receptor coactivator 3
    • pCIP
    • RAC 3
    • RAC-3
    • RAC3
    • Receptor associated coactivator 3
    • Receptor-associated coactivator 3
    • SRC 3
    • SRC-3
    • SRC3
    • Steroid receptor coactivator protein 3
    • Thyroid hormone receptor activator molecule 1
    • TNRC14
    • TNRC16
    • TRAM 1
    • TRAM-1
    • TRAM1
    see all
  • FunctionNuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. Interacts with PSMB9.
  • Tissue specificityWidely expressed. High expression in heart, skeletal muscle, pancreas and placenta. Low expression in brain, and very low in lung, liver and kidney.
  • Sequence similaritiesBelongs to the SRC/p160 nuclear receptor coactivator family.
    Contains 1 basic helix-loop-helix (bHLH) domain.
    Contains 1 PAS (PER-ARNT-SIM) domain.
  • DomainContains three Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. Motifs 1 and 2 are essential for the association with nuclear receptors, and constitute the RID domain (Receptor-interacting domain).
  • Post-translational
    Acetylated by CREBBP. Acetylation occurs in the RID domain, and disrupts the interaction with nuclear receptors and regulates its function.
    Methylated by CARM1.
    Phosphorylated by IKK complex. Regulated its function.
  • Cellular localizationCytoplasm. Nucleus. Mainly cytoplasmic and weakly nuclear. Upon TNF activation and subsequent phosphorylation, it translocates from the cytoplasm to the nucleus.
  • Information by UniProt

References for SRC3 peptide (ab4915)

ab4915 has not yet been referenced specifically in any publications.

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