Overview

  • Product nameAnti-SRD5A2 antibody
    See all SRD5A2 primary antibodies
  • Description
    Rabbit polyclonal to SRD5A2
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Rabbit, Pig
  • Immunogen

    Synthetic peptide corresponding to a region within N-terminal amino acids 1-50 of human SRD5A2 (NP_000339).

  • Positive control
    • THP-1 cell lysate

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab99065 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 28 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionConverts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
  • Tissue specificityExpressed in high levels in the prostate and many other androgen-sensitive tissues.
  • Involvement in diseaseDefects in SRD5A2 are the cause of pseudovaginal perineoscrotal hypospadias (PPSH) [MIM:264600]. A form of male pseudohermaphroditism in which 46,XY males show ambiguous genitalia at birth, including perineal hypospadias and a blind perineal pouch, and develop masculinization at puberty. The name of the disorder stems from the finding of a blind-ending perineal opening resembling a vagina and a severely hypospadiac penis with the urethra opening onto the perineum.
  • Sequence similaritiesBelongs to the steroid 5-alpha reductase family.
  • Cellular localizationMicrosome membrane. Endoplasmic reticulum membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • 3 oxo 5 alpha steroid 4 dehydrogenase 2 antibody
    • 3-oxo-5-alpha-steroid 4-dehydrogenase 2 antibody
    • 5 alpha SR2 antibody
    • 5 alpha-SR2 antibody
    • 5ART2 antibody
    • e II 5 alpha reductase antibody
    • EC antibody
    • MGC138457 antibody
    • Micropenis, included antibody
    • S5A2_HUMAN antibody
    • S5AR 2 antibody
    • SR type 2 antibody
    • SRD5A2 antibody
    • Steroid 5 alpha reductase 2 antibody
    • Steroid 5-alpha-reductase 2 antibody
    • Steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) antibody
    • Type II 5-alpha reductase antibody
    see all

Anti-SRD5A2 antibody images

  • Anti-SRD5A2 antibody (ab99065) at 1 µg/ml + THP-1 cell lysate at 10 µg

    Predicted band size : 28 kDa

References for Anti-SRD5A2 antibody (ab99065)

ab99065 has not yet been referenced specifically in any publications.

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