Anti-SRD5A2 antibody [EPR6281(B)] (ab124877)


  • Product name
    Anti-SRD5A2 antibody [EPR6281(B)]
    See all SRD5A2 primary antibodies
  • Description
    Rabbit monoclonal [EPR6281(B)] to SRD5A2
  • Tested applications
    Suitable for: WB, IPmore details
    Unsuitable for: Flow Cyt,ICC/IF or IHC-P
  • Species reactivity
    Reacts with: Rat, Human
  • Immunogen

    Synthetic peptide corresponding to residues near the N-terminus of Human SRD5A2 (P31213).

  • Positive control
    • LnCaP, Human testis, and PC-3 cell lysates
  • General notes

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

    Mouse: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.



Our Abpromise guarantee covers the use of ab124877 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Detects a band of approximately 28 kDa (predicted molecular weight: 28 kDa).
IP 1/10 - 1/100.
  • Application notes
    Is unsuitable for Flow Cyt,ICC/IF or IHC-P.
  • Target

    • Function
      Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
    • Tissue specificity
      Expressed in high levels in the prostate and many other androgen-sensitive tissues.
    • Involvement in disease
      Defects in SRD5A2 are the cause of pseudovaginal perineoscrotal hypospadias (PPSH) [MIM:264600]. A form of male pseudohermaphroditism in which 46,XY males show ambiguous genitalia at birth, including perineal hypospadias and a blind perineal pouch, and develop masculinization at puberty. The name of the disorder stems from the finding of a blind-ending perineal opening resembling a vagina and a severely hypospadiac penis with the urethra opening onto the perineum.
    • Sequence similarities
      Belongs to the steroid 5-alpha reductase family.
    • Cellular localization
      Microsome membrane. Endoplasmic reticulum membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • 3 oxo 5 alpha steroid 4 dehydrogenase 2 antibody
      • 3-oxo-5-alpha-steroid 4-dehydrogenase 2 antibody
      • 5 alpha SR2 antibody
      • 5 alpha-SR2 antibody
      • 5ART2 antibody
      • e II 5 alpha reductase antibody
      • EC antibody
      • MGC138457 antibody
      • Micropenis, included antibody
      • S5A2_HUMAN antibody
      • S5AR 2 antibody
      • SR type 2 antibody
      • SRD5A2 antibody
      • Steroid 5 alpha reductase 2 antibody
      • Steroid 5-alpha-reductase 2 antibody
      • Steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) antibody
      • Type II 5-alpha reductase antibody
      see all

    Anti-SRD5A2 antibody [EPR6281(B)] images

    • All lanes : Anti-SRD5A2 antibody [EPR6281(B)] (ab124877) at 1/1000 dilution

      Lane 1 : LnCaP cell lysate
      Lane 2 : Human testis lysate
      Lane 3 : PC3 cell lysate

      Lysates/proteins at 10 µg per lane.

      HRP labelled goat anti-rabbit at 1/2000 dilution

      Predicted band size : 28 kDa
    • Equilibrium disassociation constant (KD)
      Learn more about KD

      Click here to learn more about KD

    References for Anti-SRD5A2 antibody [EPR6281(B)] (ab124877)

    ab124877 has not yet been referenced specifically in any publications.

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