Anti-SREBP2 antibody (ab30682)

ab30682 has been referenced in 27 publications.

• Feng S  et al. NS5ABP37 inhibits liver cancer by impeding lipogenesis and cholesterogenesis. Cancer Sci 108:12-22 (2017). WB ; Human . PubMed: 27862769
• Vienken H  et al. Characterization of cholesterol homeostasis in sphingosine-1-phosphate lyase-deficient fibroblasts reveals a Niemann-Pick disease type C-like phenotype with enhanced lysosomal Ca(2+) storage. Sci Rep 7:43575 (2017). WB . PubMed: 28262793
• Mustafa M  et al. SREBP inhibition ameliorates renal injury after unilateral ureteral obstruction. Am J Physiol Renal Physiol 311:F614-25 (2016). PubMed: 27385736
• Zheng W  et al. Pathways of cholesterol homeostasis in mouse retina responsive to dietary and pharmacologic treatments. J Lipid Res 56:81-97 (2015). PubMed: 25293590
• Ma K  et al. Overactivation of intestinal SREBP2 in mice increases serum cholesterol. PLoS One 9:e84221 (2014). IHC-Fr, WB ; Mouse . PubMed: 24465397
• Yang M  et al. Identification of miR-185 as a regulator of de novo cholesterol biosynthesis and low density lipoprotein uptake. J Lipid Res 55:226-38 (2014). PubMed: 24296663
• Carrier B  et al. Alpha-lipoic acid reduces LDL-particle number and PCSK9 concentrations in high-fat fed obese Zucker rats. PLoS One 9:e90863 (2014). WB ; Rat . PubMed: 24595397
• Rauer C  et al. Sterol regulatory element-binding proteins are regulators of the rat thyroid peroxidase gene in thyroid cells. PLoS One 9:e91265 (2014). WB ; Human . PubMed: 24625548
• Nakakuki M  et al. A novel processing system of sterol regulatory element-binding protein-1c regulated by polyunsaturated fatty acid. J Biochem 155:301-13 (2014). PubMed: 24729033
• Rice LM  et al. Protein Phosphatase 2A (PP2A) Regulates Low Density Lipoprotein Uptake through Regulating Sterol Response Element-binding Protein-2 (SREBP-2) DNA Binding. J Biol Chem 289:17268-17279 (2014). WB . PubMed: 24770487
• Poirier S  et al. The epigenetic drug 5-azacytidine interferes with cholesterol and lipid metabolism. J Biol Chem 289:18736-51 (2014). WB ; Mouse, Human . PubMed: 24855646
• Barbero-Camps E  et al. Endoplasmic reticulum stress mediates amyloid ß neurotoxicity via mitochondrial cholesterol trafficking. Am J Pathol 184:2066-81 (2014). Mouse . PubMed: 24815354
• Zinkhan EK  et al. Combination of intrauterine growth restriction and a high-fat diet impairs cholesterol elimination in rats. Pediatr Res N/A:N/A (2014). Rat . PubMed: 25119340
• Valenza M  et al. Disruption of astrocyte-neuron cholesterol cross talk affects neuronal function in Huntington's disease. Cell Death Differ N/A:N/A (2014). PubMed: 25301063
• Chew WS & Ong WY Regulation of Calcium-Independent Phospholipase A2 Expression by Adrenoceptors and Sterol Regulatory Element Binding Protein-Potential Crosstalk Between Sterol and Glycerophospholipid Mediators. Mol Neurobiol N/A:N/A (2014). PubMed: 25482049
• Penque BA  et al. Hexosamine biosynthesis impairs insulin action via a cholesterolgenic response. Mol Endocrinol 27:536-47 (2013). PubMed: 23315940
• Tao R  et al. Hepatic SREBP-2 and cholesterol biosynthesis are regulated by FoxO3 and Sirt6. J Lipid Res 54:2745-53 (2013). Mouse . PubMed: 23881913
• Boschetti E  et al. Influence of genotype on the modulation of gene and protein expression by n-3 LC-PUFA in rats. Genes Nutr 8:589-600 (2013). WB ; Rat . PubMed: 23744008
• Ying Z  et al. Modified methylenedioxyphenol analogs lower LDL cholesterol through induction of LDL receptor expression. J Lipid Res 53:879-87 (2012). PubMed: 22355094
• Johnson KJ  et al. Species-specific dibutyl phthalate fetal testis endocrine disruption correlates with inhibition of SREBP2-dependent gene expression pathways. Toxicol Sci 120:460-74 (2011). Rat . PubMed: 21266533
• Spencer CM  et al. Human cytomegalovirus induces the activity and expression of acetyl-coenzyme A carboxylase, a fatty acid biosynthetic enzyme whose inhibition attenuates viral replication. J Virol 85:5814-24 (2011). PubMed: 21471234
• Luthi-Carter R  et al. SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis. Proc Natl Acad Sci U S A 107:7927-32 (2010). ICC/IF ; Drosophila melanogaster . PubMed: 20378838
• López-Soldado I  et al. Suppression of VLDL secretion by cultured hepatocytes incubated with chylomicron remnants enriched in n-3 polyunsaturated fatty acids is regulated by hepatic nuclear factor-4alpha. Biochim Biophys Acta 1791:1181-9 (2009). WB ; Rat . PubMed: 19699314
• König B  et al. Effects of fish oil and conjugated linoleic acids on expression of target genes of PPAR alpha and sterol regulatory element-binding proteins in the liver of laying hens. Br J Nutr 100:355-63 (2008). WB ; Chicken . PubMed: 18205990
• Tamboli IY  et al. Loss of gamma-secretase function impairs endocytosis of lipoprotein particles and membrane cholesterol homeostasis. J Neurosci 28:12097-106 (2008). WB ; Mouse . PubMed: 19005074
• Bell RD  et al. SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells. Nat Cell Biol : (2008). IHC-Fr, ICC/IF, WB ; Human . PubMed: 19098903
• Koch A  et al. Thermally oxidized oil increases the expression of insulin-induced genes and inhibits activation of sterol regulatory element-binding protein-2 in rat liver. J Nutr 137:2018-23 (2007). PubMed: 17709436