Anti-SREBP2 antibody (ab30682)

ab30682 has been referenced in 48 publications.

• Feng S  et al. NS5ABP37 inhibits liver cancer by impeding lipogenesis and cholesterogenesis. Cancer Sci 108:12-22 (2017). WB ; Human . PubMed: 27862769
• Vienken H  et al. Characterization of cholesterol homeostasis in sphingosine-1-phosphate lyase-deficient fibroblasts reveals a Niemann-Pick disease type C-like phenotype with enhanced lysosomal Ca(2+) storage. Sci Rep 7:43575 (2017). WB . PubMed: 28262793
• Casagrande V  et al. Hepatocyte specific TIMP3 expression prevents diet dependent fatty liver disease and hepatocellular carcinoma. Sci Rep 7:6747 (2017). WB ; Mouse . PubMed: 28751722
• Giampietro C  et al. Cholesterol impairment contributes to neuroserpin aggregation. Sci Rep 7:43669 (2017). WB . PubMed: 28255164
• Wang WA  et al. Loss of Calreticulin Uncovers a Critical Role for Calcium in Regulating Cellular Lipid Homeostasis. Sci Rep 7:5941 (2017). PubMed: 28725049
• Rideout TC  et al. Complementary Cholesterol-Lowering Response of a Phytosterol/a-Lipoic Acid Combination in Obese Zucker Rats. J Diet Suppl 13:283-99 (2016). PubMed: 25664679
• Mustafa M  et al. SREBP inhibition ameliorates renal injury after unilateral ureteral obstruction. Am J Physiol Renal Physiol 311:F614-25 (2016). PubMed: 27385736
• Morioka S  et al. TAK1 regulates hepatic lipid homeostasis through SREBP. Oncogene 35:3829-38 (2016). PubMed: 26973245
• Li X  et al. SREBP-2 promotes stem cell-like properties and metastasis by transcriptional activation of c-Myc in prostate cancer. Oncotarget 7:12869-84 (2016). WB . PubMed: 26883200
• Mishra S  et al. Accumulation of cholesterol and increased demand for zinc in serum-deprived RPE cells. Mol Vis 22:1387-1404 (2016). WB . PubMed: 28003730
• Tang H  et al. Irisin Inhibits Hepatic Cholesterol Synthesis via AMPK-SREBP2 Signaling. EBioMedicine 6:139-148 (2016). PubMed: 27211556
• Xu D  et al. PAQR3 modulates cholesterol homeostasis by anchoring Scap/SREBP complex to the Golgi apparatus. Nat Commun 6:8100 (2015). WB ; Human . PubMed: 26311497
• Kang J  et al. Simultaneous deletion of the methylcytosine oxidases Tet1 and Tet3 increases transcriptome variability in early embryogenesis. Proc Natl Acad Sci U S A 112:E4236-45 (2015). PubMed: 26199412
• Zheng W  et al. Pathways of cholesterol homeostasis in mouse retina responsive to dietary and pharmacologic treatments. J Lipid Res 56:81-97 (2015). PubMed: 25293590
• Wong TY  et al. The Flavone Luteolin Suppresses SREBP-2 Expression and Post-Translational Activation in Hepatic Cells. PLoS One 10:e0135637 (2015). WB . PubMed: 26302339
• Li M  et al. MicroRNA-185-5p mediates regulation of SREBP2 expression by hepatitis C virus core protein. World J Gastroenterol 21:4517-25 (2015). PubMed: 25914460
• Gabitova L  et al. Endogenous Sterol Metabolites Regulate Growth of EGFR/KRAS-Dependent Tumors via LXR. Cell Rep 12:1927-38 (2015). PubMed: 26344763
• Mattos KA  et al. Mycobacterium leprae intracellular survival relies on cholesterol accumulation in infected macrophages: a potential target for new drugs for leprosy treatment. Cell Microbiol 16:797-815 (2014). PubMed: 24552180
• Nikolaenko L  et al. Testosterone replacement ameliorates nonalcoholic fatty liver disease in castrated male rats. Endocrinology 155:417-28 (2014). PubMed: 24280056
• Ma K  et al. Overactivation of intestinal SREBP2 in mice increases serum cholesterol. PLoS One 9:e84221 (2014). IHC-Fr, WB ; Mouse . PubMed: 24465397
• Yang M  et al. Identification of miR-185 as a regulator of de novo cholesterol biosynthesis and low density lipoprotein uptake. J Lipid Res 55:226-38 (2014). PubMed: 24296663
• Carrier B  et al. Alpha-lipoic acid reduces LDL-particle number and PCSK9 concentrations in high-fat fed obese Zucker rats. PLoS One 9:e90863 (2014). WB ; Rat . PubMed: 24595397
• Rauer C  et al. Sterol regulatory element-binding proteins are regulators of the rat thyroid peroxidase gene in thyroid cells. PLoS One 9:e91265 (2014). WB ; Human . PubMed: 24625548
• Nakakuki M  et al. A novel processing system of sterol regulatory element-binding protein-1c regulated by polyunsaturated fatty acid. J Biochem 155:301-13 (2014). PubMed: 24729033
• Rice LM  et al. Protein Phosphatase 2A (PP2A) Regulates Low Density Lipoprotein Uptake through Regulating Sterol Response Element-binding Protein-2 (SREBP-2) DNA Binding. J Biol Chem 289:17268-17279 (2014). WB . PubMed: 24770487
• Poirier S  et al. The epigenetic drug 5-azacytidine interferes with cholesterol and lipid metabolism. J Biol Chem 289:18736-51 (2014). WB ; Mouse, Human . PubMed: 24855646
• Barbero-Camps E  et al. Endoplasmic reticulum stress mediates amyloid ß neurotoxicity via mitochondrial cholesterol trafficking. Am J Pathol 184:2066-81 (2014). Mouse . PubMed: 24815354
• Zinkhan EK  et al. Combination of intrauterine growth restriction and a high-fat diet impairs cholesterol elimination in rats. Pediatr Res N/A:N/A (2014). Rat . PubMed: 25119340
• Valenza M  et al. Disruption of astrocyte-neuron cholesterol cross talk affects neuronal function in Huntington's disease. Cell Death Differ N/A:N/A (2014). PubMed: 25301063
• Chew WS & Ong WY Regulation of Calcium-Independent Phospholipase A2 Expression by Adrenoceptors and Sterol Regulatory Element Binding Protein-Potential Crosstalk Between Sterol and Glycerophospholipid Mediators. Mol Neurobiol N/A:N/A (2014). PubMed: 25482049
• Penque BA  et al. Hexosamine biosynthesis impairs insulin action via a cholesterolgenic response. Mol Endocrinol 27:536-47 (2013). PubMed: 23315940
• Tao R  et al. Hepatic SREBP-2 and cholesterol biosynthesis are regulated by FoxO3 and Sirt6. J Lipid Res 54:2745-53 (2013). Mouse . PubMed: 23881913
• Boschetti E  et al. Influence of genotype on the modulation of gene and protein expression by n-3 LC-PUFA in rats. Genes Nutr 8:589-600 (2013). WB ; Rat . PubMed: 23744008
• Yu Y  et al. PKR-like endoplasmic reticulum kinase is necessary for lipogenic activation during HCMV infection. PLoS Pathog 9:e1003266 (2013). WB . PubMed: 23592989
• Wen S  et al. Treadmill Exercise Training Modulates Hepatic Cholesterol Metabolism and Circulating PCSK9 Concentration in High-Fat-Fed Mice. J Lipids 2013:908048 (2013). WB . PubMed: 23862065
• Wu J  et al. Kisspeptin-10 enhanced egg production in quails associated with the increase of triglyceride synthesis in liver. Asian-Australas J Anim Sci 26:1080-8 (2013). WB . PubMed: 25049888
• Daimiel LA  et al. Promoter analysis of the DHCR24 (3ß-hydroxysterol ?(24)-reductase) gene: characterization of SREBP (sterol-regulatory-element-binding protein)-mediated activation. Biosci Rep 33:57-69 (2012). PubMed: 23050906
• Hu Y  et al. In ovo leptin administration affects hepatic lipid metabolism and microRNA expression in newly hatched broiler chickens. J Anim Sci Biotechnol 3:16 (2012). WB . PubMed: 22958551
• Ying Z  et al. Modified methylenedioxyphenol analogs lower LDL cholesterol through induction of LDL receptor expression. J Lipid Res 53:879-87 (2012). PubMed: 22355094
• Johnson KJ  et al. Species-specific dibutyl phthalate fetal testis endocrine disruption correlates with inhibition of SREBP2-dependent gene expression pathways. Toxicol Sci 120:460-74 (2011). Rat . PubMed: 21266533
• Spencer CM  et al. Human cytomegalovirus induces the activity and expression of acetyl-coenzyme A carboxylase, a fatty acid biosynthetic enzyme whose inhibition attenuates viral replication. J Virol 85:5814-24 (2011). PubMed: 21471234
• Peterson TR  et al. mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway. Cell 146:408-20 (2011). PubMed: 21816276
• Luthi-Carter R  et al. SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis. Proc Natl Acad Sci U S A 107:7927-32 (2010). ICC/IF ; Drosophila melanogaster . PubMed: 20378838
• López-Soldado I  et al. Suppression of VLDL secretion by cultured hepatocytes incubated with chylomicron remnants enriched in n-3 polyunsaturated fatty acids is regulated by hepatic nuclear factor-4alpha. Biochim Biophys Acta 1791:1181-9 (2009). WB ; Rat . PubMed: 19699314
• König B  et al. Effects of fish oil and conjugated linoleic acids on expression of target genes of PPAR alpha and sterol regulatory element-binding proteins in the liver of laying hens. Br J Nutr 100:355-63 (2008). WB ; Chicken . PubMed: 18205990
• Tamboli IY  et al. Loss of gamma-secretase function impairs endocytosis of lipoprotein particles and membrane cholesterol homeostasis. J Neurosci 28:12097-106 (2008). WB ; Mouse . PubMed: 19005074
• Bell RD  et al. SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells. Nat Cell Biol : (2008). IHC-Fr, ICC/IF, WB ; Human . PubMed: 19098903
• Koch A  et al. Thermally oxidized oil increases the expression of insulin-induced genes and inhibits activation of sterol regulatory element-binding protein-2 in rat liver. J Nutr 137:2018-23 (2007). PubMed: 17709436