Overview

  • Product name
  • Description
    Rabbit polyclonal to SRPK1
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Human
    Predicted to work with: Rat, Rabbit, Horse, Guinea pig, Dog, Pig, Ferret, Rhesus monkey, Gorilla, Orangutan, Elephant
  • Immunogen

    Synthetic peptide corresponding to a region within amino acids 275-325 of Human SRPK1 (NP_003128.3).

  • Positive control
    • Human Colon Carcinoma, Ovarian Carcinoma, Testicular Seminoma and Mouse Colon Carcinoma CT26 tumor tissues

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer
    Preservative: 0.09% Sodium azide
    Constituents: 99% Tris buffered saline, 0.1% BSA
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab118793 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/500. Epitope exposure is recommended. Epitope exposure with citrate buffer will enhance staining.

Target

  • Function
    Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Hyperphosphorylates RS domain-containing proteins such as SFRS1, SFRS2 and ZRSR2 on serine residues during metaphase but at lower levels during interphase. Locks onto SFRS1 to form a stable complex and processively phosphorylates the RS domain. Appears to mediate HBV core protein phosphorylation which is a prerequisite for pregenomic RNA encapsidation into viral capsids.
  • Tissue specificity
    Isoform 2 is predominantly expressed in the testis but is also present at lower levels in heart, ovary, small intestine, liver, kidney, pancreas and skeletal muscle. Isoform 1 is only seen in the testis, at lower levels than isoform 2.
  • Sequence similarities
    Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.
    Contains 1 protein kinase domain.
  • Cellular localization
    Cytoplasm. Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • Serine/arginine rich protein specific kinase 1 antibody
    • Serine/arginine rich splicing factor kinase 1 antibody
    • Serine/arginine-rich protein-specific kinase 1 antibody
    • Serine/threonine protein kinase SRPK1 antibody
    • Serine/threonine-protein kinase SRPK1 antibody
    • SFRS protein kinase 1 antibody
    • SFRSK1 antibody
    • SR protein kinase 1 antibody
    • SR protein specific kinase 1 antibody
    • SR-protein-specific kinase 1 antibody
    • SRPK1 antibody
    • SRPK1_HUMAN antibody
    see all

Images

  • ab118793, at 1/250 dilution, staining SRPK1 in formalin-fixed, paraffin-embedded Human seminoma tissue by Immunohistochemistry with DAB staining.
  • ab118793, at 1/250 dilution, staining SRPK1 in formalin-fixed, paraffin-embedded Mouse CT26 tumor by Immunohistochemistry with DAB staining.

References

ab118793 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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