Overview

  • Product nameAnti-SRPR alpha antibody
    See all SRPR alpha primary antibodies
  • Description
    Sheep polyclonal to SRPR alpha
  • SpecificityThis antibody can immunoprecipitate both SRPR alpha and beta under non denaturing conditions.
  • Tested applicationsSuitable for: WB, IPmore details
  • Species reactivity
    Reacts with: Dog, Human
  • Immunogen

    Recombinant fragment, corresponding to amino acids 39-295 of Dog SRPR alpha, which includes part of the amino terminal SRPR beta binding region and the hinge region between it and the carboxyl-terminal GTPase domain.

  • Positive control
    • Canine microsomal protein.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: 0.08% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • PurityIgG fraction
  • Purification notesThis antibody is provided as a 0.2 µm sterile filtered solution.
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab16145 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
IP
  • Application notesIP: Use at an assay dependent dilution. Can be used to immunoprecipitate both subunits of SRPR under non-denaturing conditions.
    WB: Use at a concentration of 1 - 5 µg/ml. Detects a band of approximately 72 kDa.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionComponent of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system.
    • Sequence similaritiesBelongs to the GTP-binding SRP family.
    • Cellular localizationEndoplasmic reticulum membrane. Thought to be anchored in the membrane through an interaction with SR-beta, which contains a bona fide transmembrane domain.
    • Information by UniProt
    • Database links
    • Alternative names
      • Docking protein alpha antibody
      • DP alpha antibody
      • DP antibody
      • DP-alpha antibody
      • DPalpha antibody
      • MGC17355 antibody
      • MGC3650 antibody
      • MGC9571 antibody
      • signal recognition particle receptor (docking protein) antibody
      • Signal recognition particle receptor alpha subunit antibody
      • Signal recognition particle receptor antibody
      • Signal recognition particle receptor subunit alpha antibody
      • SR alpha antibody
      • SR-alpha antibody
      • SRalpha antibody
      • SRP alpha antibody
      • SRPalpha antibody
      • SRPR antibody
      • SRPR_HUMAN antibody
      see all

    Anti-SRPR alpha antibody images

    • ab16145 at 1µg/ml detecting SRPR alpha from canine microsomal protein by Western blot.

    References for Anti-SRPR alpha antibody (ab16145)

    This product has been referenced in:
    • Lakkaraju AK  et al. SRP keeps polypeptides translocation-competent by slowing translation to match limiting ER-targeting sites. Cell 133:440-51 (2008). WB ; Human . Read more (PubMed: 18455985) »

    See 1 Publication for this product

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    There are currently no Abreviews or Questions for ab16145.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"