Overview

  • Product name
  • Description
    Rabbit polyclonal to SRPX2
  • Specificity
    ab91584 is specific for SRPX2 and will not recognize SRPX1
  • Tested applications
    Suitable for: ICC/IF, WB, ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    A 16 amino acid synthetic peptide from near the amino terminus of Human SRPX2 (NP_055282).

  • Positive control
    • Human lung tissue lysate

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C.
  • Storage buffer
    Preservative: 0.02% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab91584 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use a concentration of 20 µg/ml.
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 53 kDa.Can be blocked with SRPX2 peptide (ab101235).
ELISA Use at an assay dependent concentration.
IHC-P Use at an assay dependent concentration.

Target

  • Function
    Acts as a ligand for the urokinase plasminogen activator surface receptor. Plays a role in angiogenesis by inducing endothelial cell migration and the formation of vascular network (cords). Involved in cellular migration and adhesion in cancer cells. Increases the phosphorylation levels of FAK. May have a role in the perisylvian region, critical for language and cognitive development.
  • Tissue specificity
    Expressed in neurons of the rolandic area of the brain (at protein level). Highly expressed in the brain, placenta, lung, trachea, uterus and adrenal gland. Weakly expressed in the peripheral blood, brain and bone marrow. Expressed in numerous cancer cell lines.
  • Involvement in disease
    Defects in SRPX2 are a cause of bilateral perisylvian polymicrogyria (BPP) [MIM:300388]. BPP is the most common form of polymicrogyria, a malformation of the cortex, in which the brain surface is irregular and the normal gyral pattern replaced by multiple small, partly fused, gyri separated by shallow sulci. BPP results in mild mental retardation, epilepsy and pseudobulbar palsy, causing difficulties with expressive speech and feeding.
    Defects in SRPX2 are a cause of rolandic epilepsy with speech dyspraxia and mental retardation X-linked (RESDX) [MIM:300643]. A condition characterized by the association of rolandic seizures with oral and speech dyspraxia, and mental retardation. Rolandic occur during a period of significant brain maturation. During this time, dysfunction of neural network activities such as focal discharges may be associated with specific developmental disabilities resulting in specific cognitive impairments of language, visuo-spatial abilities or attention.
  • Sequence similarities
    Contains 1 HYR domain.
    Contains 3 Sushi (CCP/SCR) domains.
  • Cellular localization
    Cytoplasm. Secreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • BPP antibody
    • CBPS antibody
    • PMGX antibody
    • RESDX antibody
    • SRPUL antibody
    • SRPX 2 antibody
    • SRPX2 antibody
    • SRPX2_HUMAN antibody
    • Sushi repeat containing protein SRPX2 antibody
    • Sushi repeat containing protein X linked 2 antibody
    • Sushi repeat protein antibody
    • Sushi repeat-containing protein SRPX2 antibody
    see all

Images

  • Immunofluorescence of SRPX2 in Human lung tissue with ab91584 at 20 ug/mL.

  • Immunohistochemistry of rat lung tissue with ab91584 at 5 μg/mL.

  • Lane 1 : Anti-SRPX2 antibody (ab91584) at 1 µg/ml
    Lane 2 : Anti-SRPX2 antibody (ab91584) at 2 µg/ml

    Lane 1 : Human lung tissue lysate
    Lane 2 : Human lung tissue lysate

    Lysates/proteins at 15 µg per lane.


    Predicted band size : 53 kDa

References

ab91584 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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