Overview

  • Product name
  • Description
    Mouse polyclonal to SS18
  • Tested applications
    Suitable for: WB, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length Human protein (NP_001007560.1)

  • Positive control
    • WB: A-431 cell lysate; ICC/IF: HeLa cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab89086 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 46 kDa.
ICC/IF Use a concentration of 10 µg/ml.

Target

  • Function
    Appears to function synergistically with RBM14 as a transcriptional coactivator. Isoform 1 and isoform 2 function in nuclear receptor coactivation. Isoform 1 and isoform 2 function in general transcriptional coactivation.
  • Tissue specificity
    Fairly ubiquitously expressed. Expressed in synovial sarcomas and in other human cell lines. The fusion genes SSXT-SSX1 and SSXT-SSX2 are expressed only in synovial sarcomas.
  • Involvement in disease
    Note=A chromosomal aberration involving SS18 may be a cause of synovial sarcoma. Translocation t(X;18)(p11.2;q11.2). The translocation is specifically found in more than 80% of synovial sarcoma. The fusion products SSXT-SSX1 or SSXT-SSX2 are probably responsible for transforming activity. Heterogeneity in the position of the breakpoint can occur (low frequency).
  • Sequence similarities
    Belongs to the SS18 family.
  • Cellular localization
    Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • MGC116875 antibody
    • Protein SSXT antibody
    • Protein SYT antibody
    • SS18 antibody
    • SSXT antibody
    • SSXT/SSX4v fusion antibody
    • SSXT_HUMAN antibody
    • Synovial sarcoma translocated to X chromosome antibody
    • Synovial sarcoma translocated to X chromosome protein antibody
    • Synovial sarcoma translocation chromosome 18 antibody
    • SYT antibody
    • SYT SSX1 antibody
    • SYT SSX2 antibody
    • SYT/SSX4v fusion protein antibody
    • SYTSSX1 antibody
    • SYTSSX2 antibody
    see all

Anti-SS18 antibody images

  • Anti-SS18 antibody (ab89086) at 1 µg/ml + A-431 cell lysate at 50 µg

    Predicted band size : 46 kDa
  • All lanes : Anti-SS18 antibody (ab89086) at 1 µg/ml

    Lane 1 : SS18 transfected 293T cell lysate
    Lane 2 : Non transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.


    Predicted band size : 46 kDa
  • ab89086 at 10 µg/ml staining SS18 by immunofluorescence in paraformaldehyde-fixed, permeabilized HeLa cells.

References for Anti-SS18 antibody (ab89086)

ab89086 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab89086.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up