Overview

  • Product nameAnti-SS18 antibody
    See all SS18 primary antibodies
  • Description
    Mouse polyclonal to SS18
  • Tested applicationsSuitable for: WB, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length Human protein (NP_001007560.1)

  • Positive control
    • WB: A-431 cell lysate; ICC/IF: HeLa cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab89086 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 46 kDa.
ICC/IF Use a concentration of 10 µg/ml.

Target

  • FunctionAppears to function synergistically with RBM14 as a transcriptional coactivator. Isoform 1 and isoform 2 function in nuclear receptor coactivation. Isoform 1 and isoform 2 function in general transcriptional coactivation.
  • Tissue specificityFairly ubiquitously expressed. Expressed in synovial sarcomas and in other human cell lines. The fusion genes SSXT-SSX1 and SSXT-SSX2 are expressed only in synovial sarcomas.
  • Involvement in diseaseNote=A chromosomal aberration involving SS18 may be a cause of synovial sarcoma. Translocation t(X;18)(p11.2;q11.2). The translocation is specifically found in more than 80% of synovial sarcoma. The fusion products SSXT-SSX1 or SSXT-SSX2 are probably responsible for transforming activity. Heterogeneity in the position of the breakpoint can occur (low frequency).
  • Sequence similaritiesBelongs to the SS18 family.
  • Cellular localizationNucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • MGC116875 antibody
    • Protein SSXT antibody
    • Protein SYT antibody
    • SS18 antibody
    • SSXT antibody
    • SSXT/SSX4v fusion antibody
    • SSXT_HUMAN antibody
    • Synovial sarcoma translocated to X chromosome antibody
    • Synovial sarcoma translocated to X chromosome protein antibody
    • Synovial sarcoma translocation chromosome 18 antibody
    • SYT antibody
    • SYT SSX1 antibody
    • SYT SSX2 antibody
    • SYT/SSX4v fusion protein antibody
    • SYTSSX1 antibody
    • SYTSSX2 antibody
    see all

Anti-SS18 antibody images

  • Anti-SS18 antibody (ab89086) at 1 µg/ml + A-431 cell lysate at 50 µg

    Predicted band size : 46 kDa
  • All lanes : Anti-SS18 antibody (ab89086) at 1 µg/ml

    Lane 1 : SS18 transfected 293T cell lysate
    Lane 2 : Non transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.


    Predicted band size : 46 kDa
  • ab89086 at 10 µg/ml staining SS18 by immunofluorescence in paraformaldehyde-fixed, permeabilized HeLa cells.

References for Anti-SS18 antibody (ab89086)

ab89086 has not yet been referenced specifically in any publications.

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