The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/1000. Predicted molecular weight: 158 kDa.
Different isoforms of SSH2 may produce bands at a lower molecular weight to the predicted.
Use at an assay dependent concentration.
FunctionProtein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein.
Sequence similaritiesBelongs to the protein-tyrosine phosphatase family. Contains 1 tyrosine-protein phosphatase domain.