Overview

  • Product name
  • Description
    Rabbit polyclonal to SSH3BP1
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Turkey, Pig, Chimpanzee, Rhesus monkey, Gorilla, Orangutan, Platypus
  • Immunogen

    Synthetic peptide corresponding to a region between residue 325 and 375 of human SSH3BP1 ( NP_005461.2)

  • Positive control
    • Ovarian carcinoma tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab75264 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
  • Application notes
    IHC-P: 1/100 - 1/500. Antigen retrieval with citrate buffer is not essential but may optimise staining.
    The Ab is likely to work also with frozen sections.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level.
    • Tissue specificity
      Widely expressed, with highest expression in brain.
    • Involvement in disease
      Note=A chromosomal aberration involving ABI1 is a cause of acute leukemias. Translocation t(10;11)(p11.2;q23) with MLL. ABI1 isoform 2 was found to be present in acute leukemia MLL-ABI1 fusion transcript.
    • Sequence similarities
      Belongs to the ABI family.
      Contains 1 SH3 domain.
      Contains 1 t-SNARE coiled-coil homology domain.
    • Domain
      The t-SNARE coiled-coil homology domain is necessary and sufficient for interaction with STX1A.
    • Post-translational
      modifications
      In vitro substrate for v-Abl (By similarity). Phosphorylated on tyrosine residues after serum stimulation or induction by v-Abl.
    • Cellular localization
      Cytoplasm. Nucleus. Cell projection > lamellipodium. Cell projection > filopodium. Cell projection > growth cone. Cell junction > synapse > synaptosome. Cytoplasm > cytoskeleton. Localized to protruding lamellipodia and filopodia tips. Also localized to neuronal growth cones and synaptosomes.
    • Information by UniProt
    • Database links
    • Alternative names
      • Abelson interactor 1 antibody
      • Abi-1 antibody
      • Abi1 antibody
      • ABI1_HUMAN antibody
      • Abl binding protein 4 antibody
      • Abl interactor 1 antibody
      • Abl interactor protein 1 antibody
      • Abl-binding protein 4 antibody
      • AblBP4 antibody
      • e3B1 antibody
      • Eps8 binding protein antibody
      • Eps8 SH3 domain binding protein antibody
      • Eps8 SH3 domain-binding protein antibody
      • Eps8-binding protein antibody
      • Hssh3bp1 antibody
      • Interactor protein AblBP4 antibody
      • NAP1 antibody
      • Nap1 binding protein antibody
      • Nap1-binding protein antibody
      • Nap1BP antibody
      • Spectrin SH3 domain binding protein 1 antibody
      • Spectrin SH3 domain-binding protein 1 antibody
      • SSH3BP antibody
      see all

    Images

    • 1/250 ab75264 staining formalin-fixed, paraffin-embedded human ovarian carcinoma tissue. Detection: DAB staining.

    References

    ab75264 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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