Overview

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab48571 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/312500.
WB Use a concentration of 0.5 µg/ml. Detects a band of approximately 21 kDa (predicted molecular weight: 21 kDa).Can be blocked with SSX2 peptide (ab182921). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionCould act as a modulator of transcription.
  • Tissue specificityExpressed at high level in the testis. Expressed at low level in thyroid. Not detected in tonsil, colon, lung, spleen, prostate, kidney, striated and smooth muscles. Detected in rhabdomyosarcoma and fibrosarcoma cell lines. Not detected in mesenchymal and epithelial cell lines.
  • Involvement in diseaseNote=A chromosomal aberration involving SSX2 may be a cause of synovial sarcoma. Translocation t(X;18)(p11.2;q11.2). The translocation is specifically found in more than 80% of synovial sarcoma. The fusion products SSXT-SSX1 or SSXT-SSX2 are probably responsible for transforming activity. Heterogeneity in the position of the breakpoint can occur (low frequency).
  • Sequence similaritiesBelongs to the SSX family.
    Contains 1 KRAB-related domain.
  • Cellular localizationNucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • Cancer/testis antigen 5.2 antibody
    • Cancer/testis antigen family 5, member 2a antibody
    • Cancer/testis antigen family 5, member 2b antibody
    • CT5.2 antibody
    • CT5.2A antibody
    • CT5.2b antibody
    • HD21 antibody
    • hom mel 40 antibody
    • HOM-MEL-40 antibody
    • MGC119055 antibody
    • MGC15364 antibody
    • MGC3884 antibody
    • Protein SSX2 antibody
    • RP11-552J9.2 antibody
    • sarcoma, synovial, X-chromosome related 2 antibody
    • SSx antibody
    • SSX2 antibody
    • SSX2-SYT fusion gene, included antibody
    • SSX2_HUMAN antibody
    • SSX2B antibody
    • Synovial sarcoma antibody
    • synovial sarcoma X breakpoint 2 antibody
    • Synovial sarcoma, X breakpoint 2B antibody
    • Tumor antigen HOM-MEL-40 antibody
    • X breakpoint 2 antibody
    see all

Anti-SSX2 antibody images

  • Anti-SSX2 antibody (ab48571) at 0.5 µg/ml (in 5% skim milk / PBS buffer) + Jurkat cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 21 kDa
    Observed band size : 21 kDa

References for Anti-SSX2 antibody (ab48571)

ab48571 has not yet been referenced specifically in any publications.

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