Overview

  • Product name
  • Description
    Rabbit polyclonal to ST3GAL5
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, between amino acids 396-426 from the C-terminal region of Human ST3GAL5 (NP_003887.3, NP_001035902.1).

  • Positive control
    • Jurkat cell line lysate, Human skeletal muscle

Properties

Applications

Our Abpromise guarantee covers the use of ab107534 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 48 kDa.
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function
    Catalyzes the formation of ganglioside GM3 (alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1, 4-beta-D-glucosylceramide).
  • Tissue specificity
    Ubiquitous. High expression in brain, skeletal muscle, placenta, and testis.
  • Involvement in disease
    Defects in ST3GAL5 are the cause of Amish infantile epilepsy syndrome (AIES) [MIM:609056]. AIES is an autosomal recessive, infantile-onset symptomatic epilepsy associated with developmental stagnation and blindness.
  • Sequence similarities
    Belongs to the glycosyltransferase 29 family.
  • Post-translational
    modifications
    N-glycosylated.
  • Cellular localization
    Golgi apparatus membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • 3-sialyltransferase antibody
    • CMP-NeuAc:lactosylceramide alpha-2 antibody
    • CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase antibody
    • EC 2.4.99.9 antibody
    • Ganglioside GM3 synthase antibody
    • Lactosylceramide alpha-2,3-sialyltransferase antibody
    • Sialyltransferase 9 antibody
    • SIAT9 antibody
    • SIAT9_HUMAN antibody
    • SIATGM3S antibody
    • ST3 beta-galactoside alpha-2,3-sialyltransferase 5 antibody
    • ST3GAL antibody
    • ST3Gal V antibody
    • ST3GAL5 antibody
    • ST3GalV antibody
    see all

Images

  • Anti-ST3GAL5 antibody (ab107534) at 1/100 dilution + Jurkat cell line lysate at 35 µg

    Predicted band size : 48 kDa
  • Immunohistochemistry analysis in formalin fixed and paraffin embedded Human skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining. ab107534 at a dilution of 1/50.

References

ab107534 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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