Overview

  • Product nameAnti-Stabilin 2 antibody
  • Description
    Rabbit polyclonal to Stabilin 2
  • Tested applicationsSuitable for: IHC-P, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    antigen sequence, corresponding to amino acids 1203-1334 of Human Stabilin 2. (Q8WWQ8)

  • Positive control
    • Human spleen tissue; U 251 MG cells.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab121893 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/200 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
ICC/IF Use a concentration of 1 - 4 µg/ml. Fixation/Permeabilization: PFA/Triton X-100

Target

  • FunctionPhosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that binds to and mediates endocytosis of hyaluronic acid (HA). Acts also, in different species, as a primary systemic scavenger receptor for heparin (Hep), chondroitin sulfate (CS), dermatan sulfate (DS), nonglycosaminoglycan (GAG), acetylated low-density lipoprotein (AcLDL), pro-collagen propeptides and advanced glycation end products (AGE). May serve to maintain tissue integrity by supporting extracellular matrix turnover or it may contribute to maintaining fluidity of bodily liquids by resorption of hyaluronan. Counter receptor which plays an important role in lymphocyte recruitment in the hepatic vasculature. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. The proteolytically processed 190 kDa form also functions as an endocytosis receptor for heparin internalisation as well as HA and CS.
  • Tissue specificityHighly expressed in sinusoidal endothelial cells of liver, spleen and lymph nodes. Also expressed in non SEC-cells such as HMDMs (monocyte-derivedmacrophages), HAMs (T-cell leukemia virus type 1-associated myelopathy), and several macrophage cell line.
  • Sequence similaritiesContains 17 EGF-like domains.
    Contains 7 FAS1 domains.
    Contains 2 laminin EGF-like domains.
    Contains 1 Link domain.
  • DomainRecognizes phosphatidyl serine via its epidermal growth factor-like domains.
  • Post-translational
    modifications
    Glycosylated.
    Proteolytically processed to yield a 190 kDa protein.
  • Cellular localizationCell membrane. Cytoplasm. Only a small amount appears to be present at the cell surface.
  • Information by UniProt
  • Database links
  • Alternative names
    • 190 kDa form stabilin-2 antibody
    • 190 kDa hyaluronan receptor for endocytosis antibody
    • EGF-like antibody
    • FAS1 EGF-like and X-link domain-containing adhesion molecule 2 antibody
    • Fasciclin antibody
    • FEEL-2 antibody
    • FEEL2 antibody
    • FELL antibody
    • FEX2 antibody
    • HARE antibody
    • Hyaluronan receptor for endocytosis antibody
    • laminin-type EGF-like and link domain-containing scavenger receptor 2 antibody
    • link domain-containing scavenger receptor 2 antibody
    • STAB-2 antibody
    • Stab2 antibody
    • STAB2_HUMAN antibody
    see all

Anti-Stabilin 2 antibody images

  • ab121893 at 1/200 dilution staining Stabilin 2 in Paraffin-embedded Human Spleen tissue by Immunohistochemistry.
  • ab128931 at 4 µg/ml staining Stabilin 2 in PFA/Triton X-100 fixed/permeabilized U 251 MG cells by Immunofluorescence (green).

References for Anti-Stabilin 2 antibody (ab121893)

ab121893 has not yet been referenced specifically in any publications.

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