Anti-Stabilin 2 antibody (ab121893)
Key features and details
- Rabbit polyclonal to Stabilin 2
- Suitable for: IHC-P, ICC/IF
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-Stabilin 2 antibody -
Description
Rabbit polyclonal to Stabilin 2 -
Host species
Rabbit -
Tested applications
Suitable for: IHC-P, ICC/IFmore details -
Species reactivity
Reacts with: Human -
Immunogen
antigen sequence, corresponding to amino acids 1203-1334 of Human Stabilin 2. (Q8WWQ8)
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Positive control
- Human spleen tissue; U 251 MG cells.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
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Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
pH: 7.20
Preservative: 0.02% Sodium azide
Constituents: 40% Glycerol (glycerin, glycerine), 59% PBS -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab121893 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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IHC-P |
1/500 - 1/1000. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
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ICC/IF |
Use a concentration of 0.25 - 2 µg/ml.
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Notes |
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IHC-P
1/500 - 1/1000. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
ICC/IF
Use a concentration of 0.25 - 2 µg/ml. |
Target
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Function
Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that binds to and mediates endocytosis of hyaluronic acid (HA). Acts also, in different species, as a primary systemic scavenger receptor for heparin (Hep), chondroitin sulfate (CS), dermatan sulfate (DS), nonglycosaminoglycan (GAG), acetylated low-density lipoprotein (AcLDL), pro-collagen propeptides and advanced glycation end products (AGE). May serve to maintain tissue integrity by supporting extracellular matrix turnover or it may contribute to maintaining fluidity of bodily liquids by resorption of hyaluronan. Counter receptor which plays an important role in lymphocyte recruitment in the hepatic vasculature. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. The proteolytically processed 190 kDa form also functions as an endocytosis receptor for heparin internalisation as well as HA and CS. -
Tissue specificity
Highly expressed in sinusoidal endothelial cells of liver, spleen and lymph nodes. Also expressed in non SEC-cells such as HMDMs (monocyte-derivedmacrophages), HAMs (T-cell leukemia virus type 1-associated myelopathy), and several macrophage cell line. -
Sequence similarities
Contains 17 EGF-like domains.
Contains 7 FAS1 domains.
Contains 2 laminin EGF-like domains.
Contains 1 Link domain. -
Domain
Recognizes phosphatidyl serine via its epidermal growth factor-like domains. -
Post-translational
modificationsGlycosylated.
Proteolytically processed to yield a 190 kDa protein. -
Cellular localization
Cell membrane. Cytoplasm. Only a small amount appears to be present at the cell surface. - Information by UniProt
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Database links
- Entrez Gene: 55576 Human
- Omim: 608561 Human
- SwissProt: Q8WWQ8 Human
- Unigene: 408249 Human
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Alternative names
- 190 kDa form stabilin-2 antibody
- 190 kDa hyaluronan receptor for endocytosis antibody
- EGF-like antibody
see all
Images
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ab121893 at 1/200 dilution staining Stabilin 2 in Paraffin-embedded Human Spleen tissue by Immunohistochemistry.
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ab128931 at 4 µg/ml staining Stabilin 2 in PFA/Triton X-100 fixed/permeabilized U 251 MG cells by Immunofluorescence (green).
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (2)
ab121893 has been referenced in 2 publications.
- Yong J et al. High expression of Stabilin-2 predicts poor prognosis in non-small-cell lung cancer. Bioengineered 12:3426-3433 (2021). PubMed: 34227915
- Danoy M et al. Optimized protocol for the hepatic differentiation of induced pluripotent stem cells in a fluidic microenvironment. Biotechnol Bioeng 116:1762-1776 (2019). PubMed: 30883676