Overview

  • Product nameAnti-STAM1 antibody
    See all STAM1 primary antibodies
  • Description
    Rabbit polyclonal to STAM1
  • Tested applicationsSuitable for: IPmore details
    Unsuitable for: WB
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rabbit, Guinea pig, Cow, Dog, Chimpanzee, Ferret, Rhesus monkey, Gorilla, Chinese Hamster, Orangutan
  • Immunogen

    Synthetic peptide, corresponding to a region within amino acids 400-450 of Human STAM1 (NP_003464.1).

  • Positive control
    • HeLa whole cell lysate.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab117817 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IP Use at 2-10 µg/mg of lysate.
  • Application notesIs unsuitable for WB.
  • Target

    • FunctionInvolved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.
    • Tissue specificityUbiquitously expressed.
    • Sequence similaritiesBelongs to the STAM family.
      Contains 1 ITAM domain.
      Contains 1 SH3 domain.
      Contains 1 UIM (ubiquitin-interacting motif) repeat.
      Contains 1 VHS domain.
    • Post-translational
      modifications
      Phosphorylated on Tyr-198. Phosphorylated in response to IL2, IL3, IL4, IL7, CSF2/GM-CSF, EGF and PDGFB. Phosphorylated by activated PDGFRB.
    • Cellular localizationCytoplasm. Early endosome membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • HSE1 homolog antibody
      • Signal transducing adapter molecule 1 antibody
      • signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 antibody
      • STAM antibody
      • STAM-1 antibody
      • STAM1_HUMAN antibody
      see all

    Anti-STAM1 antibody images

    • Detection of Human STAM1 in Immunoprecipitates of Whole cell lysate (1 mg for IP, 20% of IP loaded) from HeLa cells using ab117817 at 6 µg/mg of lysate. Subsequent WB detection was done using an other anti Human STAM1 antibody.
      Detection: Chemiluminescence with an exposure time of 10 seconds.

    References for Anti-STAM1 antibody (ab117817)

    ab117817 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab117817.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"