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Rabbit polyclonal to STAM1
Predicted to work with:
Recombinant fragment corresponding to a region within amino acids 147-362 of Human STAM (UniProt Q92783).
Jurkat, Raji, K562 and NCI-H929 whole cell lysates; Human colon carcinoma tissue.
Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Preservative: 0.01% Thimerosal (merthiolate) Constituents: 79% PBS, 20% Glycerol
Concentration information loading...
Immunogen affinity purified
Abpromise guarantee covers the use of
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/500 - 1/3000. Predicted molecular weight: 59 kDa.
1/100 - 1/1000.
Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.
Belongs to the STAM family.
Contains 1 ITAM domain. Contains 1 SH3 domain. Contains 1 UIM (ubiquitin-interacting motif) repeat. Contains 1 VHS domain.
Phosphorylated on Tyr-198. Phosphorylated in response to IL2, IL3, IL4, IL7, CSF2/GM-CSF, EGF and PDGFB. Phosphorylated by activated PDGFRB.
Cytoplasm. Early endosome membrane.
Information by UniProt
HSE1 homolog antibody
Signal transducing adapter molecule 1 antibody
signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 antibody
Western blot - STAM antibody (ab155527)
All lanes : Anti-STAM1 antibody (ab155527) at 1/1000 dilution Lane 1 : Jurkat whole cell lysate Lane 2 : Raji whole cell lysate Lane 3 : K562 whole cell lysate Lane 4 : NCI-H929 whole cell lysate Lysates/proteins at 30 µg per lane. Predicted band size : 59 kDa
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-STAM antibody (ab155527)
Immunohistochemical analysis of paraffin-embedded Human colon carcinoma tissue labeling STAM with ab155527 at 1/500 dilution.
has not yet been referenced specifically in any publications.
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