Anti-STAT2 antibody [19G8.H2.H6] (ab106094)

Overview

  • Product nameAnti-STAT2 antibody [19G8.H2.H6]
    See all STAT2 primary antibodies
  • Description
    Mouse monoclonal [19G8.H2.H6] to STAT2
  • Tested applicationsSuitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    A synthetic peptide corresponding to residues near the carboxy terminus of mouse STAT2 protein.

  • Positive control
    • HeLa whole cell lysate; Human skin tissue (squamous epithelium).
  • General notesExpiration date is one year from date of opening.

Properties

Applications

Our Abpromise guarantee covers the use of ab106094 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000. Predicted molecular weight: 98 kDa.
IHC-P Use a concentration of 2.5 µg/ml.

Target

  • FunctionSignal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.
  • Sequence similaritiesBelongs to the transcription factor STAT family.
    Contains 1 SH2 domain.
  • Post-translational
    modifications
    Tyrosine phosphorylated in response to IFN-alpha.
  • Cellular localizationCytoplasm. Nucleus. Translocated into the nucleus upon activation by IFN-alpha/beta.
  • Information by UniProt
  • Database links
  • Alternative names
    • Homo sapiens interferon alpha induced transcriptional activator antibody
    • interferon alpha induced transcriptional activator antibody
    • ISGF 3 antibody
    • ISGF3 antibody
    • MGC59816 antibody
    • P113 antibody
    • signal transducer and activator of transcription 2 113kD antibody
    • Signal transducer and activator of transcription 2 antibody
    • STAT113 antibody
    • Stat2 antibody
    • STAT2_HUMAN antibody
    see all

Anti-STAT2 antibody [19G8.H2.H6] images

  • Anti-STAT2 antibody [19G8.H2.H6] (ab106094) at 1/1000 dilution + HeLa whole cell lysate at 1 µg

    Predicted band size : 98 kDa
  • ab106094 at 2.5µg/ml staining STAT2 in Formalin fixed, Paraffin-embedded Human Skin (squamous epithelium) by Immunohistochemistry. Note: moderate to strong nuclear and faint to moderate cytoplasmic staining.
    The image shows the localization of the antibody as the precipitated red signal, with a hematoxylin purple nuclear counterstain.

References for Anti-STAT2 antibody [19G8.H2.H6] (ab106094)

ab106094 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"