Overview

  • Product nameAnti-STAT2 antibody
    See all STAT2 primary antibodies
  • Description
    Rabbit polyclonal to STAT2
  • Tested applicationsSuitable for: IPmore details
    Unsuitable for: WB
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Chimpanzee, Gorilla, Orangutan
  • Immunogen

    Synthetic peptide, corresponding to a region within amino acids 175-225 of Human STAT2 (NP_005410.1).

  • Positive control
    • Jurkat whole cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab124283 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IP Use at 2-10 µg/mg of lysate.
  • Application notesIs unsuitable for WB.
  • Target

    • FunctionSignal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.
    • Sequence similaritiesBelongs to the transcription factor STAT family.
      Contains 1 SH2 domain.
    • Post-translational
      modifications
      Tyrosine phosphorylated in response to IFN-alpha.
    • Cellular localizationCytoplasm. Nucleus. Translocated into the nucleus upon activation by IFN-alpha/beta.
    • Information by UniProt
    • Database links
    • Alternative names
      • Homo sapiens interferon alpha induced transcriptional activator antibody
      • interferon alpha induced transcriptional activator antibody
      • ISGF 3 antibody
      • ISGF3 antibody
      • MGC59816 antibody
      • P113 antibody
      • signal transducer and activator of transcription 2 113kD antibody
      • Signal transducer and activator of transcription 2 antibody
      • STAT113 antibody
      • Stat2 antibody
      • STAT2_HUMAN antibody
      see all

    Anti-STAT2 antibody images

    • Detection of STAT2 by Western Blot of Immunprecipitate.
      anti-STAT2 antibody at 1µg/ml staining STAT2 in Jurkat whole cell lysate immunoprecipitated using ab123283 at 6µg/mg lysate (1 mg/IP; 20% of IP loaded/lane).
      Detection: Chemiluminescence with exposure time of 3 seconds.

    References for Anti-STAT2 antibody (ab124283)

    ab124283 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab124283.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"