Anti-STAT2 (phospho Y631) antibody (ab111609)

Overview

  • Product nameAnti-STAT2 (phospho Y631) antibody
    See all STAT2 primary antibodies
  • Description
    Rabbit polyclonal to STAT2 (phospho Y631)
  • Specificityab111609 detects endogenous levels of STAT2 only when phosphorylated at tyrosine 631.
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic phosphopeptide derived from Human STAT2 around the phosphorylation site of tyrosine 631 (Q-P-YP-T-K).

  • Positive control
    • Human colon carcinoma tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab111609 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • FunctionSignal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.
  • Sequence similaritiesBelongs to the transcription factor STAT family.
    Contains 1 SH2 domain.
  • Post-translational
    modifications
    Tyrosine phosphorylated in response to IFN-alpha.
  • Cellular localizationCytoplasm. Nucleus. Translocated into the nucleus upon activation by IFN-alpha/beta.
  • Information by UniProt
  • Database links
  • Alternative names
    • Homo sapiens interferon alpha induced transcriptional activator antibody
    • interferon alpha induced transcriptional activator antibody
    • ISGF 3 antibody
    • ISGF3 antibody
    • MGC59816 antibody
    • P113 antibody
    • signal transducer and activator of transcription 2 113kD antibody
    • Signal transducer and activator of transcription 2 antibody
    • STAT113 antibody
    • Stat2 antibody
    • STAT2_HUMAN antibody
    see all

Anti-STAT2 (phospho Y631) antibody images

  • ab111609 at 1/50 dilution staining STAT2 in paraffin-embedded Human Colon carcinoma tissue by Immunohistochemistry. The image on the right is treated with the synthesized phosphopeptide.

References for Anti-STAT2 (phospho Y631) antibody (ab111609)

ab111609 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your enquiry.

Here is the link for the activated Stat1 reference we discussed:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060772/?tool=pubmed

It uses the following antibody, ab4742:

http://www.abc...

Read More

I am sorry this product did not perform as stated on the datasheet and for the inconvenience this has caused. As requested, I have issued a free of charge replacement for one vial of ab111609.


As we discussed, this antibody is backorder...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"