Overview

  • Product name
  • Description
    Rabbit polyclonal to STATIP1
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WB, IHC-P, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Cow
  • Immunogen

    Recombinant fragment corresponding to a region within internal sequence amino acids 318-620 of Human STATIP1 (UniProt ID: Q6IA86).

  • Positive control
    • HeLa nuclear cell lysate. HeLa cells. Human colon carcinoma tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab154643 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 93 kDa.
IHC-P 1/100 - 1/1000. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. Alternatively Tris-EDTA buffer (pH8.0) may be used.
ICC/IF 1/100 - 1/1000.

Target

  • Function
    Regulates the ligand-dependent activation of STAT3.
    Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4.
  • Sequence similarities
    Belongs to the WD repeat ELP2 family.
    Contains 14 WD repeats.
  • Cellular localization
    Cytoplasm. Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • AU023723 antibody
    • Elongation protein 2 homolog (S. cerevisiae) antibody
    • Elongator acetyltransferase complex subunit 2 antibody
    • Elongator complex protein 2 antibody
    • elongator protein 2 antibody
    • ELP2 antibody
    • ELP2_HUMAN antibody
    • Epl2 antibody
    • FLJ10879 antibody
    • SHINC 2 antibody
    • SHINC-2 antibody
    • SHINC2 antibody
    • signal transducer and activator of transcription 3 interacting protein 1 antibody
    • signal transducer and activator of transcription interacting protein 1 antibody
    • STAT3 interacting protein 1 antibody
    • Stat3 interacting protein antibody
    • STAT3-interacting protein 1 antibody
    • STATIP 1 antibody
    • STATIP1 antibody
    • STATIP1 protein antibody
    • StIP antibody
    • StIP1 antibody
    see all

Images

  • Anti-STATIP1 antibody (ab154643) at 1/1000 dilution + HeLa nuclear lysate at 20 µg

    Predicted band size: 93 kDa



    7.5% SDS PAGE
  • Immunofluorescent analysis of paraformaldehyde-fixed HeLa cells labeling STATIP1 with ab154643 at a 1/500 dilution. Alpha-tubulin filaments were labeled red at 1/2000.
  • Immunohistochemical analysis of paraffin embedded Human colon carcinoma tissue labelling STATIP1 with ab154643 at a 1/250 dilution.

References

This product has been referenced in:
  • Hogstrand C  et al. A mechanism for epithelial-mesenchymal transition and anoikis resistance in breast cancer triggered by zinc channel ZIP6 and STAT3 (signal transducer and activator of transcription 3). Biochem J 455:229-37 (2013). Read more (PubMed: 23919497) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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