Overview

  • Product name
    Stattic
  • Description
    Selective STAT3 inhibitor
  • Biological description
    Selective STAT3 inhibitor. Inhibits activation, dimerization and nuclear translocation of STAT3 by interacting with the SH2 domain. Displays selectivity over STAT1, STAT5, c-Myc/Max, Jun/Jun and Lck. Induces apoptosis in vitro and in vivo.
  • Purity
    > 99%

Properties

Applications

Our Abpromise guarantee covers the use of ab120952 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Functional Studies Use at an assay dependent concentration.

Images

  • ab76315 staining STAT3 (phospho Y705) in MDA-MB-231 cells treated with stattic (ab120952), by ICC/IF. Decrease in STAT3 (phospho Y705) expression correlates with increased concentration of stattic as described in literature.
    The cells were incubated at 37°C for 2h in media containing different concentrations of ab120952 (stattic) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab76315 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

References

This product has been referenced in:
  • Souissi I  et al. A STAT3-decoy oligonucleotide induces cell death in a human colorectal carcinoma cell line by blocking nuclear transfer of STAT3 and STAT3-bound NF-?B. BMC Cell Biol 12:14 (2011). Read more (PubMed: 21486470) »
  • Lin L  et al. STAT3 is necessary for proliferation and survival in colon cancer-initiating cells. Cancer Res 71:7226-37 (2011). Read more (PubMed: 21900397) »
  • Schust J  et al. Stattic: a small-molecule inhibitor of STAT3 activation and dimerization. Chem Biol 13:1235-42 (2006). Read more (PubMed: 17114005) »

See all 4 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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