Overview

  • Product name
  • Description
    Rabbit polyclonal to STAU2
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Recombinant fragment within Human STAU2 aa 2-226. The exact sequence is proprietary.
    Database link: Q9NUL3

  • Positive control
    • U87-MG cell lysate; mouse prostate tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab184009 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 63 kDa.
IHC-P 1/100 - 1/1000.

Target

  • Function
    RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite. As protein synthesis occurs within the dendrite, the localization of specific mRNAs to dendrites may be a prerequisite for neurite outgrowth and plasticity at sites distant from the cell body.
  • Sequence similarities
    Contains 4 DRBM (double-stranded RNA-binding) domains.
  • Domain
    The DRBM 3 domain appears to be the major RNA-binding determinant. This domain also mediates interaction with XPO5 and is required for XPO1/CRM1-independent nuclear export.
  • Cellular localization
    Cytoplasm. Nucleus. Nucleus > nucleolus. Endoplasmic reticulum. Shuttles between the nucleolus, nucleus and the cytoplasm. Nuclear export of isoform 1 is independent of XPO1/CRM1 and requires the exportin XPO5. Nuclear export of isoform 2 and isoform 3 can occur by both XPO1/CRM1-dependent and XPO1/CRM1-independent pathways. Found in large cytoplasmic ribonucleoprotein (RNP) granules which are present in the actin rich regions of myelinating processes and associated with microtubules, polysomes and the endoplasmic reticulum. Also recruited to stress granules (SGs) upon inhibition of translation or oxidative stress. These structures are thought to harbor housekeeping mRNAs when translation is aborted.
  • Information by UniProt
  • Database links
  • Alternative names
    • 39K2 antibody
    • 39K3 antibody
    • DKFZp781K0371 antibody
    • Double stranded RNA binding protein Staufen homolog 2 antibody
    • Double-stranded RNA-binding protein Staufen homolog 2 antibody
    • MGC119606 antibody
    • STAU 2 antibody
    • stau2 antibody
    • STAU2_HUMAN antibody
    • Staufen (Drosophila, RNA-binding protein) homolog 2 antibody
    • Staufen double-stranded RNA binding protein 2 antibody
    • Staufen homolog 2 antibody
    • Staufen RNA binding protein homolog 2 antibody
    • Staufen, RNA binding protein, homolog 2 (Drosophila) antibody
    see all

Images

  • Anti-STAU2 antibody (ab184009) at 1/500 dilution + U87-MG whole cell lysate at 30 µg

    Predicted band size : 63 kDa

    7.5% SDS-PAGE

  • Immunohistochemical analysis of paraffin-embedded mouse prostate tissue labeling STAU2 with ab184009 at 1/500 dilution.

References

ab184009 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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