Overview

  • Product name
  • Description
    Rabbit polyclonal to Staufen
  • Specificity
    At least three isoforms of Staufen are known to exist; ab105398 will detect all three.
  • Tested applications
    Suitable for: ICC/IF, WB, ICCmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    A 15 amino acid synthetic peptide from near the carboxy terminus of Human Staufen (NP_059347).(Peptide available as ab110446.)

  • Positive control
    • Rat brain tissue lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab105398 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use a concentration of 20 µg/ml.
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 63 kDa.Can be blocked with Staufen peptide (ab110446).
ICC Use a concentration of 10 µg/ml.

Target

  • Function
    Binds double-stranded RNA (regardless of the sequence) and tubulin. May play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site.
  • Tissue specificity
    Widely expressed. Expressed in brain, pancreas, heart, skeletal muscles, liver, lung, kidney and placenta.
  • Sequence similarities
    Contains 3 DRBM (double-stranded RNA-binding) domains.
  • Domain
    One of the DRDB could be involved in RER binding.
    The C-terminal contains the tubulin binding domain (TBD).
  • Cellular localization
    Cytoplasm. Rough endoplasmic reticulum. Localizes exclusively with the rough reticulum endoplasmic.
  • Information by UniProt
  • Database links
  • Alternative names
    • Double stranded RNA binding protein Staufen homolog 1 antibody
    • Double stranded RNA binding protein Staufen homolog antibody
    • Double-stranded RNA-binding protein Staufen homolog 1 antibody
    • FLJ25010 antibody
    • MGC124588 antibody
    • PPP1R150 antibody
    • STAU antibody
    • STAU1 antibody
    • STAU1_HUMAN antibody
    • staufen antibody
    • Staufen RNA binding protein (Drosophila) antibody
    • Staufen RNA binding protein homolog 1 antibody
    • Staufen, Drosophila, homolog of, 1 antibody
    • Staufen, RNA binding protein, homolog 1 (Drosophila) antibody
    • staufen-like antibody
    see all

Images

  • Lane 1 : Anti-Staufen antibody (ab105398) at 1 µg/ml
    Lane 2 : Anti-Staufen antibody (ab105398) at 2 µg/ml

    Lane 1 : Rat brain tissue lysate
    Lane 2 : Rat brain tissue lysate

    Lysates/proteins at 15 µg per lane.


    Predicted band size : 63 kDa
  • Immunohistochemistry of Staufen in Human brain tissue with ab105398 at 10 µg/ml.
  • Immunofluorescence of STAU1 in Human Brain cells using ab105398 at 20 ug/ml.

References

ab105398 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab105398.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up