Overview

  • Product nameAnti-STEAP1 antibody
    See all STEAP1 primary antibodies
  • Description
    Rabbit polyclonal to STEAP1
  • SpecificityThis antibody reacts predominantly with STEAP. Ab3679 can be used as a plasma marker for prostate cancer cells
  • Tested applicationsSuitable for: WB, IP, ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide:

    WKMKPRRNLEEDDYL

    , corresponding to amino acids 14-28 of Human STEAP.

  • Positive control
    • WB: A431 cell lysate
  • General notes


    Prostate cancer is the most frequently diagnosed cancer and is the second leading cause of cancer-related deaths in American men. Although the early serum detection of prostate-specific antigen (PSA) plays important roles in early diagnosis, it may not distinguish prostate cancer from benign diseases. Recently, a novel protein, which contains 339 amino acids, named STEAP (six transmembrane epithelial antigen of the prostate), was identified in advanced prostate cancer. STEAP is unique among the currently known prostate cancer markers because of its putative secondary structure, from which one may predict that it functions as a potential channel protein. STEAP is strongly expressed in advanced prostate cancer and some extent expression in other cancers, such as colon and ovarian cancer cell lines.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage bufferPBS with 0.02% sodium azide
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • Primary antibody notesProstate cancer is the most frequently diagnosed cancer and is the second leading cause of cancer-related deaths in American men. Although the early serum detection of prostate-specific antigen (PSA) plays important roles in early diagnosis, it may not distinguish prostate cancer from benign diseases. Recently, a novel protein, which contains 339 amino acids, named STEAP (six transmembrane epithelial antigen of the prostate), was identified in advanced prostate cancer. STEAP is unique among the currently known prostate cancer markers because of its putative secondary structure, from which one may predict that it functions as a potential channel protein. STEAP is strongly expressed in advanced prostate cancer and some extent expression in other cancers, such as colon and ovarian cancer cell lines.
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Associated products

Applications

Our Abpromise guarantee covers the use of ab3679 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.5 - 2 µg/ml. Detects a band of approximately 40 kDa (predicted molecular weight: 38 kDa).
IP Use at an assay dependent dilution.
ELISA Use at an assay dependent dilution.

Target

  • FunctionMetalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor.
  • Tissue specificityUbiquitously expressed. Highly expressed in prostate tumors.
  • Sequence similaritiesBelongs to the STEAP family.
    Contains 1 ferric oxidoreductase domain.
  • Cellular localizationEndosome membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • 2410007B19Rik antibody
    • EC 1.16.1.- antibody
    • Metalloreductase STEAP1 antibody
    • MGC19484 antibody
    • PRSS 24 antibody
    • PRSS24 antibody
    • Six transmembrane epithelial antigen of prostate antibody
    • Six transmembrane epithelial antigen of the prostate 1 antibody
    • Six transmembrane epithelial antigen of the prostate antibody
    • Six-transmembrane epithelial antigen of prostate 1 antibody
    • STEA1_HUMAN antibody
    • STEAP 1 antibody
    • Steap antibody
    • STEAP1 antibody
    see all

Anti-STEAP1 antibody images



  • Predicted band size : 38 kDa


    A431 cell lysate probed with anti-STEAP (ab3679) at 1 microgram/ml

References for Anti-STEAP1 antibody (ab3679)

ab3679 has not yet been referenced specifically in any publications.

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