Overview

  • Product name
  • Description
    Rabbit polyclonal to STEAP3
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 1-218 of Human STEAP3 (Q658P3).

  • Positive control
    • HepG2 whole cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab126068 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 54 kDa.

Target

  • Function
    Endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+). Can also reduce of Cu(2+) to Cu(1+), suggesting that it participates in copper homeostasis. Uses NADP(+) as acceptor. May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP.
  • Tissue specificity
    Expressed in adult bone marrow, placenta, liver, skeletal muscle and pancreas. Down-regulated in hepatocellular carcinoma.
  • Involvement in disease
    Anemia, hypochromic microcytic, with iron overload 2
  • Sequence similarities
    Belongs to the STEAP family.
    Contains 1 ferric oxidoreductase domain.
  • Post-translational
    modifications
    Proteolytically cleaved by RHBDL4/RHBDD1. RHBDL4/RHBDD1-induced cleavage occurs at multiple sites in a glycosylation-independent manner.
    Glycosylated.
  • Cellular localization
    Endosome membrane. Localizes to vesicular-like structures at the plasma membrane and around the nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • 1010001D01Rik antibody
    • Dudlin 2 antibody
    • Dudlin2 antibody
    • Dudulin 2 antibody
    • Dudulin-2 antibody
    • Dudulin2 antibody
    • hpHyde antibody
    • hTSAP6 antibody
    • Metalloreductase STEAP3 antibody
    • MGC93147 antibody
    • pHyde antibody
    • Six transmembrane epithelial antigen of prostate 3 antibody
    • Six transmembrane prostate protein 3 antibody
    • Six-transmembrane epithelial antigen of prostate 3 antibody
    • STEA 3 antibody
    • STEA3_HUMAN antibody
    • STEAP 3 antibody
    • STEAP family member 3 antibody
    • STEAP family member 3 metalloreductase antibody
    • STEAP3 antibody
    • STMP 3 antibody
    • STMP3 antibody
    • TSAP 6 antibody
    • TSAP6 antibody
    • Tumor suppressor activated pathway protein 6 antibody
    • Tumor suppressor pHyde antibody
    • Tumor suppressor-activated pathway protein 6 antibody
    see all

Images

  • Anti-STEAP3 antibody (ab126068) at 1/1000 dilution + HepG2 whole cell lysate at 30 µg

    Predicted band size : 54 kDa

References

ab126068 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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